Department of Urology, Osaka University Graduate School of Medicine, Osaka, Japan.
Urology. 2013 Oct;82(4):814-9. doi: 10.1016/j.urology.2013.06.023.
To clarify the probability of low serum testosterone level as a risk factor for metabolic syndrome (MS) in middle-aged men, we measured serum total testosterone (TT) and assessed several metabolic factors because the direct risk for MS has not been investigated fully in men.
This study comprised 1150 men aged ≥30 years. Physical and laboratory variables were assessed. Analyses were conducted to determine the association between serum TT level and incidence risk of MS and MS factors by a separate logistic regression model.
Mean (± standard deviation [SD]) serum TT level was 5.4 ± 1.7 ng/mL in the 1150 men, and only 92 men (8.0%) were classified as having MS by the Japanese criteria. In age-adjusted analyses, higher levels of serum TT were independently associated with a lower risk of MS (odds ratio, per SD decrement of TT, 2.3; 95% confidence interval [CI], 1.7-2.9). MS risk increased by lower quintile of TT: ORs were 15.1 (95% CI, 4.6-50.0) for first quintile, 8.8 (95% CI, 2.6-29.9) for second quintile, 5.8 (95% CI, 1.7-20.5) for third quintile, and 5.0 (95% CI, 1.4-17.9) for fourth quintile compared with highest quintile of TT. Age-adjusted ORs for the incidence of dichotomous components of MS per SD decrement of TT were 1.8 (95% CI, 1.5-2.3) for waist circumference, 1.6 (95% CI, 1.1-2.2) for dyslipidemia, and 1.5 (95% CI, 1.2-1.8) for hypertension.
We found that higher probability of MS was associated with lower levels of serum TT level in relatively healthy middle-aged Japanese men.
为了阐明中年男性低血清睾酮水平作为代谢综合征（MS）风险因素的概率，我们测量了血清总睾酮（TT）并评估了几种代谢因素，因为男性的 MS 直接风险尚未得到充分研究。
本研究纳入了 1150 名年龄≥30 岁的男性。评估了身体和实验室变量。通过单独的逻辑回归模型分析了血清 TT 水平与 MS 及 MS 因素发生风险之间的关系。
1150 名男性的平均（±标准差 [SD]）血清 TT 水平为 5.4±1.7ng/mL，仅 92 名男性（8.0%）根据日本标准被诊断为 MS。在年龄调整分析中，较高的血清 TT 水平与较低的 MS 风险独立相关（优势比，每 SD 下降 TT 的降幅，2.3；95%置信区间 [CI]，1.7-2.9）。MS 风险随着 TT 的五分位值降低而增加：第一五分位的 OR 为 15.1（95% CI，4.6-50.0），第二五分位为 8.8（95% CI，2.6-29.9），第三五分位为 5.8（95% CI，1.7-20.5），第四五分位为 5.0（95% CI，1.4-17.9）与 TT 的最高五分位相比。年龄调整后的 TT 每 SD 下降对 MS 二分法成分的发生率的 OR 分别为 1.8（95% CI，1.5-2.3）腰围、1.6（95% CI，1.1-2.2）血脂异常和 1.5（95% CI，1.2-1.8）高血压。
我们发现，在相对健康的日本中年男性中，MS 的可能性较高与血清 TT 水平较低相关。
