日本学龄期体育俱乐部所属情况与未来血清游离睾酮水平的关系：一项横断面研究。

Relation between athletic club affiliation from school age and future serum free testosterone levels in Japan: A cross-sectional study.

作者信息

Kato Yuki, Shigehara Kazuyoshi, Nakagawa Tomomi, Kawaguchi Shohei, Izumi Kouji, Kadono Yoshifumi, Mizokami Atsushi

机构信息

Department of Integrative Cancer Therapy and Urology Kanazawa University Graduate School of Medical Science Kanazawa Japan.

Depatment of Urology Wajima Municipal hospital Wajima Japan.

出版信息

Health Sci Rep. 2023 Aug 17;6(8):e1496. doi: 10.1002/hsr2.1496. eCollection 2023 Aug.

DOI:10.1002/hsr2.1496

PMID:37599654

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10435685/

Abstract

BACKGROUND AND AIMS

Testosterone deficiency is often related to geriatric syndrome including erectile dysfunction, osteo-porosis, depression, cognitive impairment, cardiovascular diseases and frailty. Despite the existence of many studies on short-term exercise and serum testosterone levels, few research have focused on exercise habits from young age and testosterone values in middle-aged male. In this study, we investigated whether belonging to an athletic club from school age could predict serum-free testosterone (FT) levels.

METHODS

The subjects were 1609 middle-aged male outpatients aged 40 years or older (median: 61 years, interquartile range: 54-69) who visited our hospital. Participants had their FT values measured in the morning hours during the period from December 2007 to June 2009. A questionnaire survey on exercise habits was conducted at the same time as the measurements. The exercise habit questionnaire was created based on whether the patients belonged to an athletic club in (a) elementary school, (b) junior high school, (c) high school, (d) college, (e) adult life, and (f) at the time of the test.

RESULTS

There was only one positive response to the questionnaire among 456 patients (28% of total), followed by zero for 358 patients (22% of total). The number of patients with low-testosterone levels (FT < 8.5 pg/mL) according to the Japanese diagnostic criteria for late-onset of hypogonadism was 839 (52.1%). In multivariate analysis, it was shown that with low-testosterone levels (FT < 8.5 pg/mL), age (odds ratio [OR]: 1.065, 95% confidence interval [CI]: 1.052-1.079; < 0.001), hypertension (OR: 3.489, 95% CI: 2.728-4.462; < 0.001), type-2 diabetes (OR: 3.035, 95% CI: 2.296-4.01; < 0.001), and dyslipidemia (OR: 2.039, 95% CI: 1.558-2.668; < 0.001) were risk factors, and more than two positive responses to the questionnaire (OR: 0.886, 95% CI: 0.802-0.980; = 0.018) were also a significant independent factor.

CONCLUSION

A sports club membership during school years may affect future testosterone levels.

摘要

背景与目的

睾酮缺乏常与老年综合征相关，包括勃起功能障碍、骨质疏松、抑郁、认知障碍、心血管疾病和虚弱。尽管已有许多关于短期运动与血清睾酮水平的研究，但很少有研究关注年轻时的运动习惯与中年男性睾酮值之间的关系。在本研究中，我们调查了从学龄期开始加入体育俱乐部是否能预测血清游离睾酮（FT）水平。

方法

研究对象为1609名40岁及以上的中年男性门诊患者（中位数：61岁，四分位间距：54 - 69岁），他们前来我院就诊。参与者于2007年12月至2009年6月期间在上午测量FT值。同时进行了关于运动习惯的问卷调查。运动习惯问卷是根据患者是否在（a）小学、（b）初中、（c）高中、（d）大学、（e）成年期以及（f）测试时加入体育俱乐部来编制的。

结果

456名患者（占总数的28%）中对问卷只有1个肯定回答，358名患者（占总数的22%）回答为零。根据日本迟发性性腺功能减退诊断标准，睾酮水平低（FT < 8.5 pg/mL）的患者有839名（52.1%）。在多变量分析中，结果显示睾酮水平低（FT < 8.5 pg/mL）时，年龄（优势比[OR]：1.065，95%置信区间[CI]：1.052 - 1.079；P < 0.001）、高血压（OR：3.489，95% CI：2.728 - 4.462；P < 0.001）、II型糖尿病（OR：3.035，95% CI：2.296 - 4.01；P < 0.001）和血脂异常（OR：2.039，95% CI：1.558 - 2.668；P < 0.001）是危险因素，对问卷有两个以上肯定回答（OR：0.886，95% CI：0.802 - 0.980；P = 0.018）也是一个显著的独立因素。