Aorta Center and Department of Thoracic and Cardiovascular Surgery, Cleveland Clinic, Cleveland, Ohio.
J Thorac Cardiovasc Surg. 2013 Dec;146(6):1408-16; discussion 1416-7. doi: 10.1016/j.jtcvs.2013.07.070. Epub 2013 Sep 24.
To compare the outcomes between patients undergoing endovascular (EEC) or open (OEC) approaches to second-stage elephant trunk completion (EC).
From 1993 to 2010, 225 patients underwent second-stage EC (EEC, n = 92; OEC, n = 133). Propensity matching was performed for a fair comparison.
The EEC patients were older, more likely to have atrial fibrillation, and had a smaller proximal aorta. The 30-day mortality was 6.2% (6.5% EEC vs 6% OEC, P = .88). No difference was found in bleeding (8.8%), stroke (3%), renal failure (4%), or spinal cord injury (4%); however, the OEC patients required tracheostomy more often (10 vs 1, P = .014). Survival after second-stage EC at 6 months and 1 and 5 years was 91%, 90%, and 77%, respectively. Survival and major morbidity did not differ after matching (44 pairs). However, the EEC group had shorter stays (9.9 ± 13 vs 13 ± 9 days, P < .0001) and received less blood (3 ± 8 vs 6 ± 8 U, P = .0001) than did the OEC group. This was maintained after matching. During follow-up, 32 endoleaks (3 type I, 27 type II, 2 type III) occurred; 26 (28%) EEC and 13 of 76 (17%) OEC patients underwent reoperation. The approach was not related to the risk of death in either hazard phase, but a larger descending diameter predicted a greater risk in the early phase.
Death and complications occur similarly after OEC or EEC. The early toll might be greater after OEC, at the cost of reintervention for EEC. EEC expands the options to older patients and allows for earlier completion. Second-stage repair should not be delayed, and all patients require lifelong imaging surveillance.
比较腔内(EEC)和开放(OEC)方法行二期象鼻手术(EC)的结果。
1993 年至 2010 年,225 例患者接受二期 EC(EEC,n=92;OEC,n=133)。采用倾向性匹配进行公平比较。
EEC 组患者年龄较大,心房颤动发生率较高,近端主动脉较小。30 天死亡率为 6.2%(EEC 组为 6.5%,OEC 组为 6%,P=0.88)。两组出血(8.8%)、卒中(3%)、肾衰竭(4%)或脊髓损伤(4%)发生率无差异;然而,OEC 组患者需要气管切开术的比例更高(10 例比 1 例,P=0.014)。二期 EC 后 6 个月、1 年和 5 年的生存率分别为 91%、90%和 77%。匹配后生存和主要并发症无差异(44 对)。然而,EEC 组住院时间较短(9.9±13 天比 13±9 天,P<0.0001),输血量较少(3±8 单位比 6±8 单位,P=0.0001)。匹配后仍保持这种情况。随访期间,发生 32 例内漏(3 型 I,27 型 II,2 型 III);26 例(28%)EEC 和 76 例中的 13 例(17%)OEC 患者再次手术。该方法与危险阶段的死亡风险无关,但降主动脉直径较大预示着早期风险更大。
OEC 或 EEC 后死亡率和并发症发生率相似。OEC 后早期病死率可能更高,EEC 则需要再次介入治疗。EEC 为老年患者提供了更多选择,并允许更早完成手术。二期修复不应延迟,所有患者均需终身影像学监测。