German Cancer Research Center (DKFZ) - Division of Clinical Epidemiology and Aging Research, Im Neuenheimer Feld, 581-69120 Heidelberg, Germany.
Cancer Epidemiol. 2013 Dec;37(6):905-7. doi: 10.1016/j.canep.2013.09.007. Epub 2013 Sep 27.
The vitamin D receptor (VDR) gene is present in colorectal cancer (CRC) cells and its genetic variants have been associated with an increased risk of CRC. The association with colorectal cancer prognosis remains widely unexplored.
1397 colorectal cancer patients participating in two cancer cohorts (ESTHER II and VERDI) and in a population-based case-control study (DACHS) were followed for 5 years. Unadjusted and adjusted hazard ratios for all-cause mortality (469 events) and CRC-specific mortality (336 events) were estimated for VDR variants rs731236 (TaqI), rs2228570 (FokI), rs11568820 (Cdx2), and rs1989969 (VDR-5132).
No association was found between VDR polymorphism and CRC specific and all-cause mortality. Adjusted hazard ratios ranged from 0.79 (95% CI 0.57-1.12) to 1.14 (95% CI 0.89-1.46) for CRC-specific mortality and from 0.89 (95% CI 0.67-1.18) to 1.22 (95% CI 0.99-1.50) for all-cause mortality. All 95% confidence intervals included the null value.
Our findings do not support the hypothesis that the common VDR gene variants investigated in this study are of clinical relevance with respect to CRC prognosis.
维生素 D 受体（VDR）基因存在于结直肠癌（CRC）细胞中，其遗传变异与 CRC 风险增加有关。其与结直肠癌预后的相关性仍未得到广泛探索。
1397 名参与两个癌症队列（ESTHER II 和 VERDI）和一项基于人群的病例对照研究（DACHS）的结直肠癌患者随访 5 年。未调整和调整后的 VDR 变体 rs731236（TaqI）、rs2228570（FokI）、rs11568820（Cdx2）和 rs1989969（VDR-5132）的全因死亡率（469 例事件）和 CRC 特异性死亡率（336 例事件）的风险比进行了估计。
VDR 多态性与 CRC 特异性和全因死亡率之间没有关联。调整后的危险比范围为 CRC 特异性死亡率的 0.79（95%CI 0.57-1.12）至 1.14（95%CI 0.89-1.46），全因死亡率的 0.89（95%CI 0.67-1.18）至 1.22（95%CI 0.99-1.50）。所有 95%置信区间均包含零值。
我们的研究结果不支持以下假设，即本研究中研究的常见 VDR 基因变异与 CRC 预后的临床相关性。
