Ashmore Joseph H, Gallagher Carla J, Lesko Samuel M, Muscat Joshua E, Hartman Terryl J, Lazarus Philip
Department of Pharmaceutical Sciences, Washington State University, Spokane, Washington.
Department of Public Health Sciences, Pennsylvania State College of Medicine, Hershey, Pennsylvania. Department of Pharmacology, Pennsylvania State College of Medicine, Hershey, Pennsylvania.
Cancer Epidemiol Biomarkers Prev. 2015 Oct;24(10):1635-7. doi: 10.1158/1055-9965.EPI-15-0284. Epub 2015 Jul 29.
Epidemiologic evidence indicates that greater intakes of vitamin D may decrease the risk of colorectal cancer. Variants in the vitamin D receptor (VDR) gene have the potential to modify associations between vitamin D intake and colorectal cancer.
Associations between intakes of vitamin D and colorectal cancer were studied in a large case-control study conducted in central and northeastern Pennsylvania including 1,012 cases with histologically confirmed colorectal cancer and 1,080 population-based controls. Associations between 35 tagSNPs encompassing the VDR gene and risk for colorectal cancer as well as gene-diet associations were also assessed among a subset of the population (770 controls, 710 cases).
No significant trends were observed between vitamin D intake and colorectal cancer risk. After adjustment for multiple comparisons, none of the SNPs or haplotypes within the VDR gene were associated with colorectal cancer. There were also no interactions between dietary factors and variants in the entire VDR gene.
Overall, results from this study suggest that vitamin D intake and variants in the VDR gene have little effect on risk for colorectal cancer.
Increasing vitamin D intake from the diet may not result in decreasing the incidence of colorectal cancer.
流行病学证据表明，摄入更多的维生素D可能会降低患结直肠癌的风险。维生素D受体（VDR）基因的变异有可能改变维生素D摄入量与结直肠癌之间的关联。
在宾夕法尼亚州中部和东北部进行的一项大型病例对照研究中，研究了维生素D摄入量与结直肠癌之间的关联，该研究包括1012例经组织学确诊的结直肠癌病例和1080例基于人群的对照。在部分人群（770例对照，710例病例）中，还评估了涵盖VDR基因的35个标签单核苷酸多态性（tagSNP）与结直肠癌风险之间的关联以及基因-饮食关联。
未观察到维生素D摄入量与结直肠癌风险之间存在显著趋势。在对多重比较进行校正后，VDR基因内的单核苷酸多态性或单倍型均与结直肠癌无关。整个VDR基因中的饮食因素与变异之间也没有相互作用。
总体而言，本研究结果表明，维生素D摄入量和VDR基因变异对结直肠癌风险影响很小。
通过饮食增加维生素D摄入量可能不会降低结直肠癌的发病率。
