启动子、营养传感器上的O-连接的N-乙酰葡糖胺化与转录调控。
O-GlcNAcylation at promoters, nutrient sensors, and transcriptional regulation.
作者信息
Lewis Brian A
机构信息
Metabolism Branch, CCR/NCI/NIH, 9000 Rockville Pike, Bethesda, MD 20892, USA.
出版信息
Biochim Biophys Acta. 2013 Nov;1829(11):1202-6. doi: 10.1016/j.bbagrm.2013.09.003. Epub 2013 Sep 25.
Abstract
Post-translational modifications play important roles in transcriptional regulation. Among the less understood PTMs is O-GlcNAcylation. Nevertheless, O-GlcNAcylation in the nucleus is found on hundreds of transcription factors and coactivators and is often found in a mutually exclusive ying-yang relationship with phosphorylation. O-GlcNAcylation also links cellular metabolism directly to the proteome, serving as a conduit of metabolic information to the nucleus. This review serves as a brief introduction to O-GlcNAcylation, emphasizing its important thematic roles in transcriptional regulation, and highlights several recent and important additions to the literature that illustrate the connections between O-GlcNAc and transcription.
摘要
翻译后修饰在转录调控中发挥着重要作用。在了解较少的翻译后修饰中，O-连接的N-乙酰葡糖胺化（O-GlcNAcylation）便是其中之一。然而，细胞核中的O-GlcNAcylation存在于数百种转录因子和共激活因子上，并且常常与磷酸化处于一种相互排斥的阴阳关系中。O-GlcNAcylation还将细胞代谢直接与蛋白质组联系起来，作为代谢信息传递至细胞核的一条途径。本综述简要介绍了O-GlcNAcylation，强调其在转录调控中的重要主题作用，并突出了文献中一些近期的重要补充内容，这些内容阐明了O-GlcNAc与转录之间的联系。
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