INTEMA, Universidad Nacional del Mar del Plata-CONICET, Juan B. Justo 4302, B7608FDQ Mar del Plata, Argentina.
J Struct Biol. 2013 Nov;184(2):164-72. doi: 10.1016/j.jsb.2013.09.016. Epub 2013 Sep 27.
Surface modification of surgical stainless steel implants by sol gel coatings has been proposed as a tool to generate a surface that besides being protective could also create a "bioactive" interface to generate a natural bonding between the metal surface and the existing bone. The aim of this work is to analyze the quality and bone formation around hybrid bioactive coatings containing glass-ceramic particles, made by sol-gel process on 316L stainless steel used as permanent implant in terms of mineralization, calcium content and bone maturity with micro Raman, X-ray microfluorescence and X-ray absorption techniques. Uncoated implants seem to generate a thin bone layer at the beginning of osseointegration process and then this layer being separated from the surface with time. The hybrid coatings without glass-ceramic particles generate new bone around implants, with high concentration of Ca and P at the implant/tissue interface. This fact seems to be related with the presence of silica nanoparticles in the layer. The addition of bioactive particles promotes and enhances the bone quality with a homogeneous Ca and P content and a low rate of beta carbonate substitution and crystallinity, similar to young and mechanical resistant bone.
通过溶胶-凝胶涂层对手术不锈钢植入物进行表面改性，被提议作为一种生成表面的工具，该表面不仅具有保护性，还可以产生“生物活性”界面，从而在金属表面和现有骨骼之间产生自然结合。本工作旨在通过微拉曼、X 射线微荧光和 X 射线吸收技术，分析含有玻璃陶瓷颗粒的混合生物活性涂层的质量和周围骨形成情况，这些涂层是通过溶胶-凝胶工艺在 316L 不锈钢上制成的，用作永久性植入物。在骨整合过程开始时，未涂层的植入物似乎在表面生成了一层薄骨层，然后随着时间的推移，这层骨层与表面分离。不含玻璃陶瓷颗粒的混合涂层在植入物周围生成新骨，在植入物/组织界面处具有高浓度的 Ca 和 P。这一事实似乎与层中存在的硅纳米颗粒有关。生物活性颗粒的添加促进并增强了骨质量，具有均匀的 Ca 和 P 含量以及低的β碳酸根取代率和结晶度，类似于年轻且机械抗性强的骨。
