角质形成细胞脂质包膜（CLE）的形成与功能。
Formation and functions of the corneocyte lipid envelope (CLE).
作者信息
Elias Peter M, Gruber Robert, Crumrine Debra, Menon Gopinathan, Williams Mary L, Wakefield Joan S, Holleran Walter M, Uchida Yoshikazu
机构信息
Dermatology Services, Veterans Affairs Medical Center, San Francisco, CA, USA; Department of Dermatology, University of California, San Francisco, CA, USA.
Dermatology Services, Veterans Affairs Medical Center, San Francisco, CA, USA; Department of Dermatology, Innsbruck Medical University, Innsbruck, Austria; Department of Dermatology, University of California, San Francisco, CA, USA.
出版信息
Biochim Biophys Acta. 2014 Mar;1841(3):314-8. doi: 10.1016/j.bbalip.2013.09.011. Epub 2013 Sep 27.
Abstract
Corneocytes in mammalian stratum corneum are surrounded by a monolayer of covalently bound ω-OH-ceramides that form the corneocyte (-bound) lipid envelope (CLE). We review here the structure, composition, and possible functions of this structure, with insights provided by inherited and acquired disorders of lipid metabolism. This article is part of a Special Issue entitled The Important Role of Lipids in the Epidermis and their Role in the Formation and Maintenance of the Cutaneous Barrier. Guest Editors: Kenneth R. Feingold and Peter Elias.
摘要
哺乳动物角质层中的角质形成细胞被一层共价结合的ω-羟基神经酰胺单层所包围，这些神经酰胺形成了角质形成细胞（结合的）脂质包膜（CLE）。我们在此综述该结构的结构、组成和可能的功能，并从脂质代谢的遗传性和获得性疾病中获得相关见解。本文是名为“脂质在表皮中的重要作用及其在皮肤屏障形成和维持中的作用”的特刊的一部分。客座编辑：肯尼斯·R·费因戈尔德和彼得·埃利亚斯。
相似文献
1
Formation and functions of the corneocyte lipid envelope (CLE).角质形成细胞脂质包膜（CLE）的形成与功能。
Biochim Biophys Acta. 2014 Mar;1841(3):314-8. doi: 10.1016/j.bbalip.2013.09.011. Epub 2013 Sep 27.
2
The role of sphingolipid metabolism in cutaneous permeability barrier formation.鞘脂代谢在皮肤渗透屏障形成中的作用。
Biochim Biophys Acta. 2014 Mar;1841(3):441-52. doi: 10.1016/j.bbalip.2013.08.010. Epub 2013 Aug 15.
3
The important role of epidermal triacylglycerol metabolism for maintenance of the skin permeability barrier function.表皮三酰甘油代谢对维持皮肤渗透屏障功能的重要作用。
Biochim Biophys Acta. 2014 Mar;1841(3):409-15. doi: 10.1016/j.bbalip.2013.07.013. Epub 2013 Aug 6.
4
The importance of the lipoxygenase-hepoxilin pathway in the mammalian epidermal barrier.脂氧合酶-肝氧素途径在哺乳动物表皮屏障中的重要性。
Biochim Biophys Acta. 2014 Mar;1841(3):401-8. doi: 10.1016/j.bbalip.2013.08.020. Epub 2013 Sep 7.
5
The important role of stratum corneum lipids for the cutaneous barrier function.角质层脂质对皮肤屏障功能的重要作用。
Biochim Biophys Acta. 2014 Mar;1841(3):295-313. doi: 10.1016/j.bbalip.2013.11.006. Epub 2013 Nov 16.
6
Lipid Metabolic Events Underlying the Formation of the Corneocyte Lipid Envelope.角质细胞脂质包膜形成的脂质代谢事件。
Skin Pharmacol Physiol. 2021;34(1):38-50. doi: 10.1159/000513261. Epub 2021 Feb 10.
7
Role of lipids in the formation and maintenance of the cutaneous permeability barrier.脂质在皮肤渗透屏障形成与维持中的作用。
Biochim Biophys Acta. 2014 Mar;1841(3):280-94. doi: 10.1016/j.bbalip.2013.11.007. Epub 2013 Nov 18.
8
Omega-hydroxyceramides are required for corneocyte lipid envelope (CLE) formation and normal epidermal permeability barrier function.ω-羟基神经酰胺是角质形成细胞脂质包膜（CLE）形成和正常表皮渗透屏障功能所必需的。
J Invest Dermatol. 2000 Jan;114(1):185-92. doi: 10.1046/j.1523-1747.2000.00846.x.
9
Corneocyte lipid envelope (CLE), the key structure for skin barrier function and ichthyosis pathogenesis.角朊细胞脂质包膜（CLE），皮肤屏障功能和鱼鳞病发病机制的关键结构。
J Dermatol Sci. 2017 Oct;88(1):3-9. doi: 10.1016/j.jdermsci.2017.06.002. Epub 2017 Jun 8.
10
Fatty aldehyde and fatty alcohol metabolism: review and importance for epidermal structure and function.脂肪醛和脂肪醇代谢：综述及其对表皮结构和功能的重要性
Biochim Biophys Acta. 2014 Mar;1841(3):377-89. doi: 10.1016/j.bbalip.2013.09.001. Epub 2013 Sep 12.
引用本文的文献
1
Comprehensive bioinformatics analysis of EXOSC family genes in head and neck squamous cell carcinoma.头颈部鳞状细胞癌中EXOSC家族基因的综合生物信息学分析
Sci Rep. 2025 Aug 19;15(1):30361. doi: 10.1038/s41598-025-15758-3.
2
Development of Human Skin Equivalents with Inducible Ceramide Depletion for In Vitro Modeling of Lipid Impairment.用于脂质损伤体外建模的可诱导神经酰胺耗竭的人皮肤等效物的开发。
JID Innov. 2025 May 14;5(4):100383. doi: 10.1016/j.xjidi.2025.100383. eCollection 2025 Jul.
3
The origin of hydroxy-cyclohexenone fatty acids from skin barrier protein and relevance to covalent binding of ceramides.皮肤屏障蛋白中羟基环己烯酮脂肪酸的来源及其与神经酰胺共价结合的相关性。
J Lipid Res. 2025 Jul;66(7):100843. doi: 10.1016/j.jlr.2025.100843. Epub 2025 Jun 14.
4
Electroactive Electrospun Nanofibrous Scaffolds: Innovative Approaches for Improved Skin Wound Healing.电活性电纺纳米纤维支架：改善皮肤伤口愈合的创新方法。
Adv Sci (Weinh). 2025 May;12(18):e2416267. doi: 10.1002/advs.202416267. Epub 2025 Apr 7.
5
Intragenic PNPLA1 duplication in Labrador retrievers with nonepidermolytic ichthyosis.患有非表皮松解性鱼鳞病的拉布拉多寻回犬的PNPLA1基因内重复
Vet Dermatol. 2025 Jun;36(3):314-320. doi: 10.1111/vde.13341. Epub 2025 Mar 27.
6
Relationship between time-dependent epidermal ceramide composition changes and skin barrier function in adult mice.成年小鼠中随时间变化的表皮神经酰胺成分变化与皮肤屏障功能之间的关系
Mol Biol Cell. 2025 May 1;36(5):ar57. doi: 10.1091/mbc.E24-12-0551. Epub 2025 Mar 12.
7
The Octadecanoids: Synthesis and Bioactivity of 18-Carbon Oxygenated Fatty Acids in Mammals, Bacteria, and Fungi.十八烷类化合物：哺乳动物、细菌和真菌中含18个碳原子的含氧脂肪酸的合成与生物活性
Chem Rev. 2025 Jan 8;125(1):1-90. doi: 10.1021/acs.chemrev.3c00520. Epub 2024 Dec 16.
8
Epidermal RORα Maintains Barrier Integrity and Prevents Allergic Inflammation by Regulating Late Differentiation and Lipid Metabolism.表皮 RORα 通过调节晚期分化和脂质代谢维持屏障完整性并预防过敏炎症。
Int J Mol Sci. 2024 Oct 4;25(19):10698. doi: 10.3390/ijms251910698.
9
Skin Lipid Barrier: Structure, Function and Metabolism.皮肤脂质屏障：结构、功能与代谢
Allergy Asthma Immunol Res. 2024 Sep;16(5):445-461. doi: 10.4168/aair.2024.16.5.445.
10
Spatial distribution of active compounds in stratum corneum-partitioning between corneocytes and lipid matrix.角质层中活性化合物的空间分布-角质细胞和脂质基质之间的分配。
Sci Rep. 2024 Aug 12;14(1):18681. doi: 10.1038/s41598-024-66418-x.
本文引用的文献
1
Aloxe3 knockout mice reveal a function of epidermal lipoxygenase-3 as hepoxilin synthase and its pivotal role in barrier formation.Aloxe3 敲除小鼠揭示了表皮脂氧合酶-3 作为海鞘素合酶的功能及其在屏障形成中的关键作用。
J Invest Dermatol. 2013 Jan;133(1):172-80. doi: 10.1038/jid.2012.250. Epub 2012 Jul 26.
2
Cellular changes that accompany shedding of human corneocytes.伴随人类角质细胞脱落的细胞变化。
J Invest Dermatol. 2012 Oct;132(10):2430-2439. doi: 10.1038/jid.2012.173. Epub 2012 Jun 28.
3
Lipoxygenases mediate the effect of essential fatty acid in skin barrier formation: a proposed role in releasing omega-hydroxyceramide for construction of the corneocyte lipid envelope.脂氧合酶介导必需脂肪酸在皮肤屏障形成中的作用：在释放用于构建角质细胞脂质包膜的ω-羟基神经酰胺中的作用。
J Biol Chem. 2011 Jul 8;286(27):24046-56. doi: 10.1074/jbc.M111.251496. Epub 2011 May 10.
4
Revised nomenclature and classification of inherited ichthyoses: results of the First Ichthyosis Consensus Conference in Sorèze 2009.遗传性鱼鳞病的修订命名和分类：2009 年索雷兹第一次鱼鳞病共识会议的结果。
J Am Acad Dermatol. 2010 Oct;63(4):607-41. doi: 10.1016/j.jaad.2009.11.020.
5
Neutral lipid storage leads to acylceramide deficiency, likely contributing to the pathogenesis of Dorfman-Chanarin syndrome.中性脂质储存导致酰基神经酰胺缺乏，这可能是导致 Dorfman-Chanarin 综合征发病机制的原因之一。
J Invest Dermatol. 2010 Oct;130(10):2497-9. doi: 10.1038/jid.2010.145. Epub 2010 Jun 3.
6
Neutral lipid storage disease: genetic disorders caused by mutations in adipose triglyceride lipase/PNPLA2 or CGI-58/ABHD5.中性脂质贮积病：由脂肪甘油三酯脂肪酶/PNPLA2或CGI-58/ABHD5突变引起的遗传性疾病。
Am J Physiol Endocrinol Metab. 2009 Aug;297(2):E289-96. doi: 10.1152/ajpendo.00099.2009. Epub 2009 Apr 28.
7
Epidermal ceramidase activity regulates epidermal desquamation via stratum corneum acidification.表皮神经酰胺酶活性通过角质层酸化调节表皮脱屑。
Skin Pharmacol Physiol. 2008;21(2):111-8. doi: 10.1159/000114872. Epub 2008 Feb 5.
8
Pathogenesis of permeability barrier abnormalities in the ichthyoses: inherited disorders of lipid metabolism.鱼鳞病中通透性屏障异常的发病机制：脂质代谢的遗传性疾病。
J Lipid Res. 2008 Apr;49(4):697-714. doi: 10.1194/jlr.R800002-JLR200. Epub 2008 Feb 2.
9
The hepoxilin connection in the epidermis.表皮中的肝氧素联系
FEBS J. 2007 Jul;274(14):3494-3502. doi: 10.1111/j.1742-4658.2007.05909.x. Epub 2007 Jul 2.
10
12R-lipoxygenase deficiency disrupts epidermal barrier function.12R-脂氧合酶缺乏会破坏表皮屏障功能。
J Cell Biol. 2007 Apr 9;177(1):173-82. doi: 10.1083/jcb.200612116. Epub 2007 Apr 2.
Zotero 插件