角质形成细胞脂质包膜（CLE）的形成与功能。
Formation and functions of the corneocyte lipid envelope (CLE).
作者信息
Elias Peter M, Gruber Robert, Crumrine Debra, Menon Gopinathan, Williams Mary L, Wakefield Joan S, Holleran Walter M, Uchida Yoshikazu
机构信息
Dermatology Services, Veterans Affairs Medical Center, San Francisco, CA, USA; Department of Dermatology, University of California, San Francisco, CA, USA.
Dermatology Services, Veterans Affairs Medical Center, San Francisco, CA, USA; Department of Dermatology, Innsbruck Medical University, Innsbruck, Austria; Department of Dermatology, University of California, San Francisco, CA, USA.
出版信息
Biochim Biophys Acta. 2014 Mar;1841(3):314-8. doi: 10.1016/j.bbalip.2013.09.011. Epub 2013 Sep 27.
Abstract
Corneocytes in mammalian stratum corneum are surrounded by a monolayer of covalently bound ω-OH-ceramides that form the corneocyte (-bound) lipid envelope (CLE). We review here the structure, composition, and possible functions of this structure, with insights provided by inherited and acquired disorders of lipid metabolism. This article is part of a Special Issue entitled The Important Role of Lipids in the Epidermis and their Role in the Formation and Maintenance of the Cutaneous Barrier. Guest Editors: Kenneth R. Feingold and Peter Elias.
摘要
哺乳动物角质层中的角质形成细胞被一层共价结合的ω-羟基神经酰胺单层所包围，这些神经酰胺形成了角质形成细胞（结合的）脂质包膜（CLE）。我们在此综述该结构的结构、组成和可能的功能，并从脂质代谢的遗传性和获得性疾病中获得相关见解。本文是名为“脂质在表皮中的重要作用及其在皮肤屏障形成和维持中的作用”的特刊的一部分。客座编辑：肯尼斯·R·费因戈尔德和彼得·埃利亚斯。
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