van Smeden J, Janssens M, Gooris G S, Bouwstra J A
Department of Drug Delivery Technology, Leiden Academic Centre for Drug Research, Leiden University, Leiden, The Netherlands.
Department of Drug Delivery Technology, Leiden Academic Centre for Drug Research, Leiden University, Leiden, The Netherlands.
Biochim Biophys Acta. 2014 Mar;1841(3):295-313. doi: 10.1016/j.bbalip.2013.11.006. Epub 2013 Nov 16.
The skin protects the body from unwanted influences from the environment as well as excessive water loss. The barrier function of the skin is located in the stratum corneum (SC). The SC consists of corneocytes embedded in a lipid matrix. This lipid matrix is crucial for the lipid skin barrier function. This paper provides an overview of the reported SC lipid composition and organization mainly focusing on healthy and diseased human skin. In addition, an overview is provided on the data describing the relation between lipid modulations and the impaired skin barrier function. Finally, the use of in vitro lipid models for a better understanding of the relation between the lipid composition, lipid organization and skin lipid barrier is discussed. This article is part of a Special Issue entitled The Important Role of Lipids in the Epidermis and their Role in the Formation and Maintenance of the Cutaneous Barrier. This article is part of a Special Issue entitled The Important Role of Lipids in the Epidermis and their Role in the Formation and Maintenance of the Cutaneous Barrier. Guest Editors: Kenneth R. Feingold and Peter Elias.
皮肤保护身体免受来自环境的不良影响以及防止水分过度流失。皮肤的屏障功能位于角质层（SC）。角质层由嵌入脂质基质中的角质形成细胞组成。这种脂质基质对于皮肤脂质屏障功能至关重要。本文概述了已报道的角质层脂质组成和结构，主要聚焦于健康和患病的人类皮肤。此外，还概述了描述脂质调节与受损皮肤屏障功能之间关系的数据。最后，讨论了使用体外脂质模型以更好地理解脂质组成、脂质结构与皮肤脂质屏障之间的关系。本文是名为“脂质在表皮中的重要作用及其在皮肤屏障形成和维持中的作用”特刊的一部分。本文是名为“脂质在表皮中的重要作用及其在皮肤屏障形成和维持中的作用”特刊的一部分。客座编辑：肯尼斯·R·费因戈尔德和彼得·埃利亚斯。
