Department of Clinical Laboratory Sciences and Medical Biotechnology, National Taiwan University College of Medicine.
Clin Infect Dis. 2014 Jan;58(2):242-6. doi: 10.1093/cid/cit638. Epub 2013 Sep 27.
We describe the clinical course and virological characteristics of the first H7N9 influenza case in a Taiwanese patient; this patient had detectable viruses in the airway for 2 weeks, during which time an oseltamivir resistance-associated R292K mutation rapidly emerged. Anti-H7N9 antibody was detected 21 days after onset of symptoms, when H7N9 viral load declined significantly.
我们描述了首例台湾地区人感染 H7N9 流感病例的临床经过和病毒学特征；该患者在呼吸道中可检出病毒达 2 周，在此期间，奥司他韦耐药相关的 R292K 突变迅速出现。在症状出现后 21 天检测到抗 H7N9 抗体，此时 H7N9 病毒载量显著下降。
