6-（取代亚甲基）青霉烯类，细菌β-内酰胺酶的强效广谱抑制剂。II. 外消旋呋喃基和噻吩基衍生物。
6-(substituted methylene)penems, potent broad spectrum inhibitors of bacterial beta-lactamase. II. Racemic furyl and thienyl derivatives.
作者信息
Broom N J, Coleman K, Hunter P A, Osborne N F
机构信息
Beecham Pharmaceuticals, Chemotherapeutic Research Centre, Betchworth, Surrey, UK.
出版信息
J Antibiot (Tokyo). 1990 Jan;43(1):76-82. doi: 10.7164/antibiotics.43.76.
PMID:2407709
Abstract
A series of racemic 6-(substituted methylene)penems have been prepared. These compounds contain a 5-membered monoheteroaromatic ring at C-8. The antibacterial/synergistic and beta-lactamase inhibitory activities of both E- and Z-isomers and 2-substituted derivatives are compared.
摘要
已制备了一系列外消旋的6-（取代亚甲基）青霉烯。这些化合物在C-8位含有一个五元单杂芳环。比较了E-异构体和Z-异构体以及2-取代衍生物的抗菌/协同活性和β-内酰胺酶抑制活性。
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