Cattoen C, Duflos D, Bouillet L, Chatelain C, Mazars E
Département de Microbiologie, Centre Hospitalier, Valenciennes, France.
Pathol Biol (Paris). 1997 May;45(5):425-9.
The in vitro antibacterial activity of cefotaxime, cefepime and cefpirome was evaluated alone and in association with two beta-lactamase inhibitors: clavulanic acid and sulbactam against 65 extended broad spectrum beta-lactamase producing enterobacteriaceae strains [Klebsiella pneumoniae (35), Proteus mirabilis (9), Escherichia coli (11), Enterobacter aerogenes (10)]. The lowest MICs were observed for cefepime and cefpirome used alone. In association with inhibitors cefotaxime was less effective against E. aerogenes. Most isolates of K. pneumoniae, P. mirabilis, E. coli were susceptible to all the different tested associations.
对头孢噻肟、头孢吡肟和头孢匹罗的体外抗菌活性进行了单独评估，并与两种β-内酰胺酶抑制剂：克拉维酸和舒巴坦联合，针对65株产超广谱β-内酰胺酶的肠杆菌科菌株[肺炎克雷伯菌（35株）、奇异变形杆菌（9株）、大肠埃希菌（11株）、产气肠杆菌（10株）]进行了评估。单独使用时，头孢吡肟和头孢匹罗的最低抑菌浓度最低。与抑制剂联合使用时，头孢噻肟对产气肠杆菌的效果较差。大多数肺炎克雷伯菌、奇异变形杆菌、大肠埃希菌分离株对所有不同的测试联合用药均敏感。
