Department of Pharmacy and Pharmaceutical Technology, School of Pharmacy, University of Granada, Campus of Cartuja, s/n, 18071 s/n Granada, Spain.
Department of Drug Sciences, University of Pavia, viale Taramelli 12, 27100 Pavia, Italy.
Colloids Surf B Biointerfaces. 2014 Jan 1;113:152-7. doi: 10.1016/j.colsurfb.2013.08.043. Epub 2013 Sep 5.
Biopolymer chitosan/montmorillonite nanocomposites loaded with silver sulfadiazine for wound healing purposes were prepared via intercalation solution technique. Structure and morphology of loaded nanocomposites were studied and compared with pure components and unloaded nanocomposites. X-ray diffraction, Fourier transformed infrared spectroscopy, high resolution transmission electron microscopy coupled with energy-dispersion X-ray analysis, thermal and elemental analysis were employed for the characterisation. The results confirmed that the drug was effectively loaded in the three-dimensional nanocomposite structures, in which chitosan chains were adsorbed in monolayers into the clay mineral interlayer spaces.
采用插层溶液技术制备了用于伤口愈合目的的载银磺胺嘧啶的生物聚合物壳聚糖/蒙脱土纳米复合材料。对负载纳米复合材料的结构和形态进行了研究，并与纯组分和未负载纳米复合材料进行了比较。采用 X 射线衍射、傅里叶变换红外光谱、高分辨率透射电子显微镜结合能谱分析、热分析和元素分析对其进行了表征。结果证实，药物有效地负载在三维纳米复合材料结构中，其中壳聚糖链以单层形式吸附在粘土矿物的层间空间中。
