Rev Neurosci. 2013;24(5):471-84. doi: 10.1515/revneuro-2013-0017.
Over the past decade, the function of the cytoskeleton has been studied extensively in developing and mature neurons. Actin, a major cytoskeletal protein, is indispensable for the structural integrity and plasticity of neurons and their synapses. Disruption of actin dynamics has significant consequence for neurons, neuronal circuits, and the functions they govern. In particular, cell adhesion molecules, members of the Rho family of GTPases, and actin-binding proteins are important modulators of actin dynamics and neuronal as well as behavioral plasticity. In this review, we discuss recent advances in Drosophila that highlight the importance of actin regulatory proteins in mediating fly behaviors such as circadian rhythm, courtship behavior, learning and memory, and the development of drug addiction.
在过去的十年中，细胞骨架的功能在发育和成熟神经元中得到了广泛的研究。肌动蛋白是一种主要的细胞骨架蛋白，对于神经元及其突触的结构完整性和可塑性是不可或缺的。肌动蛋白动力学的破坏对神经元、神经元回路及其所控制的功能有重大影响。特别是细胞黏附分子、Rho 家族 GTPases 的成员和肌动蛋白结合蛋白是肌动蛋白动力学以及神经元和行为可塑性的重要调节剂。在这篇综述中，我们讨论了果蝇中的最新进展，这些进展强调了肌动蛋白调节蛋白在调节果蝇行为（如昼夜节律、求偶行为、学习和记忆以及药物成瘾的发展）中的重要性。
