肌动蛋白细胞骨架调节酶在药物成瘾中的新兴作用：肌动蛋白还是反应？
Emerging roles of actin cytoskeleton regulating enzymes in drug addiction: actin or reactin'?
机构信息
Department of Psychiatry, UT Southwestern Medical Center, Dallas, TX 75390, United States.
出版信息
Curr Opin Neurobiol. 2013 Aug;23(4):507-12. doi: 10.1016/j.conb.2013.01.027. Epub 2013 Feb 18.
Abstract
Neurons rely on their cytoskeleton to give them shape and stability, and on cytoskeletal dynamics for growth and synaptic plasticity. Because drug addiction is increasingly seen as the inappropriate learning of strongly reinforcing stimuli, the role of the cytoskeleton in shaping drug memories has been of increasing interest in recent years. Does the cytoskeleton have an active role in shaping these memories, and to what extent do alterations in the cytoskeleton reflect the acute actions of drug exposure, or homeostatic reactions to the chronic exposure to drugs of abuse? Here we will review recent advances in understanding the role of the cytoskeleton in the development of drug addiction, with a focus on actin filaments, as they have been studied in greater detail.
摘要
神经元依赖细胞骨架来赋予其形状和稳定性，并依赖细胞骨架的动态变化来实现生长和突触可塑性。由于成瘾越来越被视为对强烈强化刺激的不适当学习，因此近年来，细胞骨架在塑造药物记忆中的作用引起了越来越多的关注。细胞骨架在塑造这些记忆中是否具有积极作用，以及细胞骨架的改变在多大程度上反映了药物暴露的急性作用，或者是对滥用药物的慢性暴露的平衡反应？在这里，我们将回顾近年来对细胞骨架在药物成瘾发展中的作用的理解进展，重点关注肌动蛋白丝，因为它们已经得到了更详细的研究。
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