AIDS Behav. 2014 Jul;18(7):1352-8. doi: 10.1007/s10461-013-0619-5.
There is little or no data examining the association between either pain or the use or misuse of opioid analgesic with adherence to antiretroviral medications (ARVs) among HIV-infected adults. We interviewed a community-based cohort of HIV-infected indigent adults prescribed antiretroviral medications (ARVs) quarterly to examine the association between (1) pain, (2) receipt of opioid analgesics, and (3) opioid analgesic misuse with self-reported ARV adherence. Of 281 participants, most (82.5 %) reported severe or moderate pain, half (52.4 %) received a prescription for opioids, and one quarter (24.6 %) misused opioid analgesics. Most (71.9 %) reported >90 % ARV adherence. In a GEE model, neither pain (unadjusted OR 1.14, CI 0.90–1.45) nor prescription of opioid analgesics (unadjusted OR 1.11, CI 0.84–1.49) were significantly associated with ARV adherence. Misuse of opioid analgesics was associated with incomplete adherence (AOR 1.42, CI 1.09–1.86). Individuals who misuse opioid analgesics, like those who use illicit substances, may have difficulty adhering to medication regimens.
几乎没有数据研究在艾滋病毒感染的成年人中，疼痛或阿片类镇痛药的使用或滥用与抗逆转录病毒药物 (ARV) 依从性之间的关系。我们采访了一个基于社区的艾滋病毒感染贫困成年人队列，他们每季度服用抗逆转录病毒药物 (ARV)，以研究以下方面之间的关联：（1）疼痛，（2）接受阿片类镇痛药，和（3）阿片类镇痛药滥用与自我报告的 ARV 依从性之间的关系。在 281 名参与者中，大多数（82.5%）报告有严重或中度疼痛，一半（52.4%）收到了阿片类药物处方，四分之一（24.6%）滥用阿片类镇痛药。大多数（71.9%）报告了 >90%的 ARV 依从性。在 GEE 模型中，疼痛（未调整的 OR 1.14，CI 0.90-1.45）或阿片类镇痛药处方（未调整的 OR 1.11，CI 0.84-1.49）均与 ARV 依从性无显著关联。阿片类镇痛药滥用与不完全依从性相关（AOR 1.42，CI 1.09-1.86）。滥用阿片类镇痛药的个体与使用非法药物的个体一样，可能难以遵守药物治疗方案。
