Gonzalez-Garcia Marian, Ferrer Maria Jose, Borras Xavier, Muñoz-Moreno Jose A, Miranda Cristina, Puig Jordi, Perez-Alvarez Nuria, Soler Joaquim, Feliu-Soler Albert, Clotet Bonaventura, Fumaz Carmina R
Universitat Autònoma de Barcelona, Bellaterra, Barcelona, Spain.
AIDS Behav. 2014 Apr;18(4):676-685. doi: 10.1007/s10461-013-0612-z. Epub 2013 Sep 28.
Long-term diagnosed and treated HIV-infected patients have to cope with a wide range of challenges that threaten their ability to age successfully. We report the results of a randomized controlled trial testing the effects of a mindfulness-based cognitive therapy (MBCT) program on quality of life (QoL), emotional status, and immune status over a 3-month period. Forty HIV-infected patients diagnosed prior to 1996 and on cART for a minimum of 5 years were randomized to follow an MBCT program (n = 20) or remain as controls (routine follow-up) (n = 20). A regression analysis was performed, and the measurement of effect size was estimated using Cohen's d. QoL, psychological stress, depressive symptoms, and anxiety symptoms improved in the MBCT group compared with the control group. During follow-up, patients in the MBCT group had a significantly increased CD4 cell count. Effect sizes for MBCT on the variables assessed were large (d = 0.8). The findings suggest that this program may help to promote successful aging in these patients.
长期接受诊断和治疗的HIV感染患者必须应对一系列威胁其成功衰老能力的挑战。我们报告了一项随机对照试验的结果，该试验测试了基于正念的认知疗法（MBCT）项目在3个月期间对生活质量（QoL）、情绪状态和免疫状态的影响。40名在1996年之前被诊断出感染HIV且接受抗逆转录病毒治疗（cART）至少5年的患者被随机分为两组，一组参加MBCT项目（n = 20），另一组作为对照组（常规随访）（n = 20）。进行了回归分析，并使用科恩d值估计效应大小。与对照组相比，MBCT组的生活质量、心理压力、抑郁症状和焦虑症状均有所改善。在随访期间，MBCT组患者的CD4细胞计数显著增加。MBCT对所评估变量的效应大小较大（d = 0.8）。研究结果表明，该项目可能有助于促进这些患者的成功衰老。
