Department of Surgery, Teikyo University School of Medicine, 2-11-1 Kaga Itabashi-ku, Tokyo, 173-8605, Japan,
Surg Today. 2014 Apr;44(4):712-5. doi: 10.1007/s00595-013-0743-x. Epub 2013 Sep 27.
There is no established treatment for intercostal neuralgia associated with thoracotomy. We investigated the administration of pregabalin as a new perioperative treatment, assessing its safety and efficacy for intercostal neuralgia after thoracotomy.
Thirty patients suffering pain after thoracotomy severe enough to cause insomnia were prospectively enrolled and treated with 150 mg of pregabalin. We evaluated pain scores (Numeric Rating Scale, NRS), severity of nocturnal insomnia, and adverse effects before and after pregabalin administration.
We noted significant decreases in pain scores, before vs. after pregabalin administration, from 8.2 ± 1.3 to 3.4 ± 1.3 (p < 0.0001), with improvement in nocturnal insomnia in 29 out of 30 patients. Eight patients reported adverse effects, including dizziness and daytime drowsiness; however, by reducing the dose of pregabalin, these effects were minimized while pain was controlled well.
Pregabalin was highly effective for neuralgia associated with intercostal damage after thoracotomy.
开胸术后肋间神经痛尚无既定的治疗方法。我们研究了普瑞巴林作为一种新的围手术期治疗方法，评估其在开胸术后肋间神经痛的安全性和疗效。
前瞻性纳入 30 例因开胸术后疼痛导致失眠的患者，给予普瑞巴林 150mg。我们评估了普瑞巴林给药前后的疼痛评分（数字评分量表，NRS）、夜间失眠严重程度和不良反应。
与普瑞巴林给药前相比，疼痛评分显著降低，从 8.2±1.3 降至 3.4±1.3（p<0.0001），30 例患者中有 29 例夜间失眠得到改善。8 例患者报告有不良反应，包括头晕和白天嗜睡；然而，通过减少普瑞巴林的剂量，在控制疼痛的同时，这些不良反应最小化。
普瑞巴林对开胸术后肋间神经损伤引起的神经痛非常有效。
