College of Chemistry & Chemical Engineering, Longdong University, Qingyang 745000, P. R. China, (phone: +86-934-8658532; fax: +86-934-8651531).
Chem Biodivers. 2013 Sep;10(9):1623-9. doi: 10.1002/cbdv.201200262.
Four diterpenoids, including two new ones, namely noracanthopanin A (1) and acanthopanolide B (2), and two known ones, ent-pimara-9(11),15-dien-19-oic acid (3) and ent-kaur-16-en-19-oic acid (4), were isolated from the stem bark of Acanthopanax brachypus Harms. Their structures were elucidated by physicochemical and spectroscopic analyses. Compound 1 and 2 exhibited moderate cytotoxicities against HO-8910 cells with IC50 values of 65.21±0.23 and 31.43±1.01 μg/ml, respectively, and 2 showed selective weak cytotoxicity against SMMC-7721 cells (IC50 89.67±2.54 μg/ml).
从短梗五加的茎皮中分离得到了 4 个二萜类化合物，包括 2 个新化合物，即 noracanthopanin A（1）和 acanthopanolide B（2），以及 2 个已知化合物，ent-pimara-9(11),15-dien-19-oic acid（3）和 ent-kaur-16-en-19-oic acid（4）。通过理化分析和光谱分析确定了它们的结构。化合物 1 和 2 对 HO-8910 细胞表现出中等的细胞毒性，IC50 值分别为 65.21±0.23 和 31.43±1.01μg/ml，2 对 SMMC-7721 细胞表现出选择性的弱细胞毒性（IC50 为 89.67±2.54μg/ml）。
