[从大血藤茎中分离得到的一种新木脂素]

[A new lignan from stems of Sargentodoxa cuneata].

作者信息

Yuan Xian-Da, Gao Hui-Min, Chen Liang-Mian, Zhang Qi-Wei, Wang Zhi-Min

机构信息

Institute of China Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China.

出版信息

Zhongguo Zhong Yao Za Zhi. 2013 Jul;38(13):2118-24.

PMID:24079238

Abstract

Sargentodoxae Caulis was prepared from the stems of Sargentodoxa cuneata. Twenty compounds from the the stems of S. cuneata collected in Huangshan Mountain, Anhui province, were isolated and purified by column chromatography on macroporous resin (HPD100), silica gel, Sephadex LH-20 and semi-preparative HPLC. Their structures were elucidated on the basis of physico-chemical properties and spectral data analyses as (7R,8S)-3,3 '-5-trimethoxy-4,9-dihydroxy-4',7-expoxy-5',8-lignan-7'-en-9'-oic acid 4-O-beta-D-glucopyranoside(1), 1-O-(vanillic acid) -6-O-vanilloyl-beta-D-glucopyranoside(2), 4-hydroxyphenylethyl-6-O-coumaroyl-beta-D-glucopyranoside(3), citrusin B(4), cinnamoside(5), (-) -isolariciresinol 4'-O-beta-D-glucopyranoside (6), (-) -isolariciresinol 4-O-beta-D-glucopyranoside (7), 1-O-(vanillic acid) -6-(3", 5"-dimethoxy-galloyl) -beta-D-glucopyranoside (8), 4-hydroxyphenyl-ethyl-6-O-(E) -caffeoyl-beta-D-glucopyranoside (9), (-)-syringaresinol 4'-O-beta-D-glucopyranoside (10), (-)-syringaresinol di-O-beta-D-glucopyranoside (11), aegineoside (12), calceolarioside B (13), 4-hydroxy-3-methoxy-acetophenone-4-O-alpha-L-rhamnopyranosyl-(1 --> 6)-beta-D-glucopyranoside (14), 4-hydroxy-3-methoxy-acetophenone-4-O-beta-D-apiofuranosyl-(1 --> 6) -beta-D-glucopyranoside (15), (-) -epicatechin (16), salidroside (17), 3,4-dihydroxy-phenyl ethyl-beta-D-glucopyranoside (18), chlorogenic acid (19) and protocatechuic acid (20). Compound 1 was a new compound and compounds 2-7 were isolated from this plant for the first time.

摘要

大血藤是由大血藤的茎制备而成。从安徽省黄山采集的大血藤茎中分离出20种化合物，并通过大孔树脂（HPD100）柱色谱、硅胶柱色谱、Sephadex LH - 20柱色谱和半制备高效液相色谱进行纯化。根据理化性质和光谱数据分析确定它们的结构分别为：(7R,8S)-3,3'-5-三甲氧基-4,9-二羟基-4',7-环氧-5',8-木脂素-7'-烯-9'-酸4-O-β-D-吡喃葡萄糖苷(1)、1-O-(香草酸)-6-O-香草酰基-β-D-吡喃葡萄糖苷(2)、4-羟基苯乙基-6-O-香豆酰基-β-D-吡喃葡萄糖苷(3)、柑橘苷B(4)、桂皮苷(5)、(-)-异落叶松脂醇4'-O-β-D-吡喃葡萄糖苷(6)、(-)-异落叶松脂醇4-O-β-D-吡喃葡萄糖苷(7)、1-O-(香草酸)-6-(3",5"-二甲氧基-没食子酰基)-β-D-吡喃葡萄糖苷(8)、4-羟基苯乙基-6-O-(E)-咖啡酰基-β-D-吡喃葡萄糖苷(9)、(-)-紫丁香树脂醇4'-O-β-D-吡喃葡萄糖苷(10)、(-)-紫丁香树脂醇二-O-β-D-吡喃葡萄糖苷(11)、芹菜苷(12)、大车前苷B(13)、4-羟基-3-甲氧基苯乙酮-4-O-α-L-鼠李糖基-(1→6)-β-D-吡喃葡萄糖苷(14)、4-羟基-3-甲氧基苯乙酮-4-O-β-D-阿吡喃糖基-(1→6)-β-D-吡喃葡萄糖苷(15)、(-)-表儿茶素(16)、红景天苷(17)、3,4-二羟基苯乙基-β-D-吡喃葡萄糖苷(18)、绿原酸(19)和原儿茶酸(20)。化合物1是新化合物，化合物2 - 7是首次从该植物中分离得到。