[来自传统蒙药长松萝的化学成分]

[Chemical constituents from Usnea longgisima, a traditional mongolian medicine].

作者信息

Laxinamu Jila, Tang Yan-Xia, Bao Hai-Ying, Bau Tolgor

机构信息

Institute of Mycology Research, Jilin Agricultural University, Changchun 130118, China.

出版信息

Zhongguo Zhong Yao Za Zhi. 2013 Jul;38(13):2125-8.

PMID:24079239

Abstract

OBJECTIVE

To study the chemical constituents of the whole lichen of Usnea longissima.

METHOD

The compounds were separated by silica gel, Sephadex LH-20 chromatography and high performance liquid chromatography (HPLC). The structures of the compounds isolated were identified by physico-chemical properties and spectral analysis.

RESULT

Ten compounds were isolated and their structures were identified as (4aR,9bS)-2,6-diactyl-3,4a,7,9-tetrahydroxy-8,9b-dimethyl-1-oxo-1,4,4a, 9b-tetrahydrodibenzo [b,d]furan (1), (+)-usnic acid (2), orcinol (3), 18R-hydroxydihydroalloprotolichensterinic acid (4), 5, 8-epidioxy-5alpha, 8alpha-ergosta-6, 22E-dien-3beta-ol (5), ethyl everninate (6), arabitol(7), apigenin 7-O-beta-D-glucuronide (8), 3-hydroxy-5-methoxy-2-methylbenzoic acid(9), friedelin(10).

CONCLUSION

Compound 1 was a new compound. Compound 8 was isolated from genu Usnea for the first time and compounds 3, 4 and 7 were isolated from U. longissima for the first time.

摘要

目的

研究长松萝全草的化学成分。

方法

采用硅胶柱色谱、葡聚糖凝胶LH - 20柱色谱和高效液相色谱（HPLC）分离化合物。通过理化性质和光谱分析鉴定所分离化合物的结构。

结果

分离得到10个化合物，其结构分别鉴定为(4aR,9bS)-2,6 - 二乙酰基 - 3,4a,7,9 - 四羟基 - 8,9b - 二甲基 - 1 - 氧代 - 1,4,4a,9b - 四氢二苯并[b,d]呋喃（1）、(+)-松萝酸（2）、苔黑酚（3）、18R - 羟基二氢别原地衣硬脂酸（4）、5,8 - 环氧 - 5α,8α - 麦角甾 - 6,22E - 二烯 - 3β - 醇（5）、扁枝衣酸乙酯（6）、阿拉伯糖醇（7）、芹菜素7 - O - β - D - 葡糖醛酸苷（8）、3 - 羟基 - 5 - 甲氧基 - 2 - 甲基苯甲酸（9）、木栓酮（10）。