Li Mingfen, Liu Ye, Wu Yi, Liu Sirao, Jia Jie, Zhang Liqing
1Department of Rehabilitation, Huashan Hospital, Fudan University, Shanghai, China.
Int J Neurosci. 2014 Jun;124(6):403-15. doi: 10.3109/00207454.2013.850082. Epub 2013 Oct 31.
We investigated the efficacy of motor imagery-based Brain Computer Interface (MI-based BCI) training for eight stroke patients with severe upper extremity paralysis using longitudinal clinical assessments. The results were compared with those of a control group (n = 7) that only received FES (Functional Electrical Stimulation) treatment besides conventional therapies. During rehabilitation training, changes in the motor function of the upper extremity and in the neurophysiologic electroencephalographic (EEG) were observed for two groups. After 8 weeks of training, a significant improvement in the motor function of the upper extremity for the BCI group was confirmed (p < 0.05 for ARAT), simultaneously with the activation of bilateral cerebral hemispheres. Additionally, event-related desynchronization (ERD) of the affected sensorimotor cortexes (SMCs) was significantly enhanced when compared to the pretraining course, which was only observed in the BCI group (p < 0.05). Furthermore, the activation of affected SMC and parietal lobe were determined to contribute to motor function recovery (p < 0.05). In brief, our findings demonstrate that MI-based BCI training can enhance the motor function of the upper extremity for stroke patients by inducing the optimal cerebral motor functional reorganization.
我们通过纵向临床评估，研究了基于运动想象的脑机接口（MI-based BCI）训练对八名患有严重上肢瘫痪的中风患者的疗效。将结果与仅接受除传统疗法外的功能性电刺激（FES）治疗的对照组（n = 7）进行比较。在康复训练期间，观察了两组患者上肢运动功能和神经生理脑电图（EEG）的变化。训练8周后，BCI组上肢运动功能有显著改善（ARAT的p < 0.05），同时双侧大脑半球被激活。此外，与训练前相比，患侧感觉运动皮层（SMC）的事件相关去同步化（ERD）显著增强，这仅在BCI组中观察到（p < 0.05）。此外，确定患侧SMC和顶叶的激活有助于运动功能恢复（p < 0.05）。简而言之，我们的研究结果表明，基于MI的BCI训练可以通过诱导最佳的大脑运动功能重组来增强中风患者上肢的运动功能。
