Bi Rui, Zhao Liansheng, Zhang Chen, Lu Weihong, Feng Jia-Qi, Wang Yingcheng, Ni Jianliang, Zhang Jiangtao, Li Guo-Dong, Hu Qiu-Xiang, Wang Dong, Yao Yong-Gang, Li Tao
Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Kunming, Yunnan 650223, China; University of Chinese Academy of Sciences, Beijing, China.
Neurobiol Aging. 2014 Feb;35(2):444.e5-9. doi: 10.1016/j.neurobiolaging.2013.08.013. Epub 2013 Sep 27.
The leucine-rich repeat kinase-2 (LRRK2) gene has been regarded as 1 of the most common genetic causes of Parkinson's disease (PD). We hypothesized that LRRK2-susceptible allele(s) for PD might pose a risk for Alzheimer's disease (AD). In this study, we screened 12 LRRK2 gene variants in 2 independent cohorts from southwestern China (341 AD patients and 435 normal individuals) and eastern China (297 AD patients and 384 normal individuals), to discern the potential association between this gene and AD. No variant was identified to be associated with AD in either case-control sample. As both of the cohorts were of Han Chinese origin, we combined the LRRK2 variant data for the 2 sample sets together (a total of 638 AD patients and 819 normal individuals) and still found no association between the LRRK2 gene and AD, suggesting that LRRK2 gene variants may not affect the development of AD in Han Chinese individuals.
富含亮氨酸重复激酶2（LRRK2）基因被认为是帕金森病（PD）最常见的遗传病因之一。我们推测，PD的LRRK2易感等位基因可能会增加患阿尔茨海默病（AD）的风险。在本研究中，我们在中国西南部（341例AD患者和435例正常个体）和中国东部（297例AD患者和384例正常个体）的2个独立队列中筛选了12种LRRK2基因变体，以确定该基因与AD之间的潜在关联。在任何病例对照样本中均未发现与AD相关的变体。由于两个队列均为汉族，我们将两个样本集的LRRK2变体数据合并在一起（共638例AD患者和819例正常个体），仍然未发现LRRK2基因与AD之间存在关联，这表明LRRK2基因变体可能不会影响汉族个体AD的发生发展。
