Queen's Building, School of Allied Health Professions, University of East Anglia, Norwich Research Park, Norwich NR4 7TJ, UK.
Rheumatology (Oxford). 2014 Jan;53(1):114-22. doi: 10.1093/rheumatology/ket317. Epub 2013 Sep 29.
This study examines the reported evidence of an association between benign joint hypermobility syndrome (BJHS) and psychological symptoms.
A systematic review of published (AMED, CINAHL, MEDLINE, EMBASE, PubMed, Cochrane Library) and unpublished research databases (OpenGrey, the World Health Organization (WHO) International Clinical Trials Registry Platform, Current Controlled Trials, the UK National Research Register Archive) was performed from their inception to January 2013. Studies assessing the prevalence and incidence of psychological conditions for people diagnosed with BJHS were included. Meta-analysis assessing the odds ratio (OR) and standardized mean difference in severity of psychological conditions was performed. Methodological quality was assessed using the Critical Appraisal Skills Programme (CASP) appraisal tools.
Fourteen papers including 3957 participants, 1006 people with and 2951 controls without BJHS were eligible. The overall methodological quality was moderate. The results indicated that people with BJHS experience significantly greater perceptions of fear and more intense fear (P < 0.05) and have a higher probability of demonstrating agoraphobia (P < 0.05), anxiety (OR 4.39, 95% CI 1.92, 10.40), depression (OR 4.10, 95% CI 1.79, 9.41) and panic disorders (OR 6.72, 95% CI 2.22, 20.35) than those without BJHS (P ≤ 0.005). Neither anxiety nor depression have been assessed in childhood populations.
People with BJHS commonly exhibit a range of symptoms related to anxiety and depression. Considerable emotional symptoms accompany BJHS. Further study is warranted to explore how these results relate to non-Mediterranean populations and children. However, the data suggest that targeting psychological symptoms could be an important approach to managing the range of symptoms reported in these patients.
本研究旨在探讨良性关节过度活动综合征（BJHS）与心理症状之间关联的报告证据。
对已发表的（AMED、CINAHL、MEDLINE、EMBASE、PubMed、Cochrane 图书馆）和未发表的研究数据库（OpenGrey、世界卫生组织（WHO）国际临床试验注册平台、当前对照试验、英国国家研究注册档案馆）进行了系统检索，检索时间从数据库建立至 2013 年 1 月。纳入评估诊断为 BJHS 患者心理状况发生率和患病率的研究。采用优势比（OR）和心理状况严重程度的标准化均数差进行荟萃分析。采用关键评估技能计划（CASP）评估工具评估方法学质量。
共有 14 篇论文纳入研究，共纳入 3957 名参与者，其中 1006 人患有 BJHS，2951 人无 BJHS。整体方法学质量为中等。结果表明，患有 BJHS 的患者更易感到恐惧，恐惧程度更高（P < 0.05），出现广场恐惧症（P < 0.05）、焦虑症（OR 4.39，95% CI 1.92，10.40）、抑郁症（OR 4.10，95% CI 1.79，9.41）和惊恐障碍（OR 6.72，95% CI 2.22，20.35）的概率更高，而无 BJHS 的患者则没有（P ≤ 0.005）。在儿童人群中，尚未评估焦虑症和抑郁症。
患有 BJHS 的患者通常会出现一系列与焦虑和抑郁相关的症状。BJHS 患者常伴有明显的情绪症状。需要进一步研究来探讨这些结果与非地中海人群和儿童的关系。然而，这些数据表明，针对心理症状可能是管理这些患者报告的一系列症状的重要方法。
