Iuliano A Danielle, Weidle Paul J, Brooks John T, Masaba Rose, Girde Sonali, Ndivo Richard, Ogindo Paul, Omolo Paul, Zeh Clement, Thomas Timothy K
Division of HIV/AIDS Prevention, National Center for HIV, Hepatitis, STD and TB Prevention, Centers for Disease Control and Prevention, Atlanta, GA, USA
Division of HIV/AIDS Prevention, National Center for HIV, Hepatitis, STD and TB Prevention, Centers for Disease Control and Prevention, Atlanta, GA, USA.
J Int Assoc Provid AIDS Care. 2015 May-Jun;14(3):261-8. doi: 10.1177/2325957413502543. Epub 2013 Sep 30.
Absolute neutrophil counts (ANCs) are lower in East African adults. To assess the impact of lower ANCs, we reviewed data from HIV-infected Kenyan women receiving antiretroviral therapy antepartum and postpartum.
The Kisumu Breastfeeding Study (KiBS) participants received an antiretroviral regimen from 34 weeks' gestation through 6 months postpartum. Measured ANCs and subsequent illnesses were reviewed. Adverse events (AEs) potentially attributable to neutropenia were identified, and ANCs were graded using the 2004 Division of AIDS table for Grading the Severity of AEs.
Among 478 women with ≥1 postpartum ANC measured, 298 (62.1%) women met criteria for an AE (<1.3 × 10(9) cells/L). Of those, 38 (12.5%) women experienced a nonlife-threatening illness potentially attributable to neutropenia.
More than half of KiBS women met criteria for neutropenia. The mild clinical experience of most participants with low ANCs supports that these values might be typical for this population and may not result in adverse clinical sequelae.
东非成年人的绝对中性粒细胞计数（ANC）较低。为评估较低的ANC的影响，我们回顾了接受产前和产后抗逆转录病毒治疗的肯尼亚感染HIV妇女的数据。
基苏木母乳喂养研究（KiBS）的参与者从妊娠34周开始至产后6个月接受抗逆转录病毒治疗方案。对测量的ANC和随后发生的疾病进行了回顾。确定了可能归因于中性粒细胞减少的不良事件（AE），并使用2004年艾滋病司AE严重程度分级表对ANC进行分级。
在478名产后至少测量过1次ANC的妇女中，298名（62.1%）妇女符合AE标准（<1.3×10⁹个细胞/L）。其中，38名（12.5%）妇女经历了可能归因于中性粒细胞减少的非危及生命的疾病。
超过一半的KiBS妇女符合中性粒细胞减少的标准。大多数ANC较低的参与者的轻微临床经历表明，这些数值可能是该人群的典型情况，可能不会导致不良临床后果。
