白细胞介素 1B 基因+3954 位点 C/T 多态性与中国西部地区人群胃癌易感性的关联。
Association of the IL-1B +3954 C/T polymorphism with the risk of gastric cancer in a population in Western China.
机构信息
Departments of aEpidemiology bChild and Adolescent Health, West China School of Public Health, Sichuan University, Chengdu cDepartment of Infectious Diseases, Hangzhou Center for Disease Control and Prevention, Hangzhou, China dCancer Science Institute of Singapore, National University of Singapore eDepartment of Pathology, National University Health System, Singapore, Singapore fSchool of Surgery, The University of Western Australia, Perth, Western Australia, Australia gDepartment of Epidemiology and Biostatistics, Imperial College London, London, UK hInstitute of Health Sciences, University of Oulu, Oulu, Finland.
出版信息
Eur J Cancer Prev. 2014 Jan;23(1):35-42. doi: 10.1097/CEJ.0b013e3283656380.
With an estimate of 380 000 new cases each year, gastric cancer (GC) is one of the most frequently occurring cancers in China. Genes encoding proinflammatory and anti-inflammatory cytokines are good candidates for the study of susceptibility to GC. We tested the hypothesis that the polymorphisms of interleukin 1B (IL-1B) and IL-1RN contribute toward host susceptibility to GC. In a matched case-control design, we enrolled 308 pairs of GC and control participants between October 2010 and August 2011. We sequenced IL-1B +3954 C/T, IL-1RN -9876 G/A, -9739 A/G, and IL-1RN -9091 A/C using MALDI-TOF MS and collected demographic data as well as lifestyle factors using a questionnaire. GC patients reported statistically significantly greater proportions with family history of cancer (29.9 vs. 10.7%, P<0.01) and alcohol drinking (54.5 vs. 43.2%, P<0.01) than the controls. The proportion of irregular eaters was statistically higher among the patients than among the controls (66.7 vs. 24.4%, P<0.01). The IL-1B +3954 CT or the TT variant genotype was statistically significantly associated with a risk of GC [adjusted odds ratio (OR), 2.94; 95% confidence interval (CI), 1.06-8.15], whereas variants of IL-1RN -9876 G/A, IL-1RN -9739 A/G, and IL-1RN -9091 A/C were not associated (adjusted OR, 1.29, 95% CI, 0.77-2.16; adjusted OR, 1.25, 95% CI, 0.75-2.07; adjusted OR, 1.09, 95% CI, 0.71-1.67, respectively). Haplotypes established from the three polymorphisms of IL-1RN were not associated with a risk of GC. The IL-1B +3954 C/T polymorphism is associated with a risk of GC in our study. Lifestyle and environmental factors such as drinking, eating irregularly, and family history of cancer increase the risk.
在中国，每年约有 38 万例新发病例，胃癌（GC）是最常见的癌症之一。编码前炎症和抗炎细胞因子的基因是研究 GC 易感性的良好候选基因。我们假设白细胞介素 1B（IL-1B）和 IL-1RN 的多态性有助于宿主对 GC 的易感性。采用病例对照设计，我们于 2010 年 10 月至 2011 年 8 月招募了 308 对 GC 患者和对照参与者。我们使用基质辅助激光解吸电离飞行时间质谱法（MALDI-TOF MS）对 IL-1B+3954C/T、IL-1RN-9876G/A、-9739A/G 和 IL-1RN-9091A/C 进行测序，并使用问卷收集人口统计学数据和生活方式因素。GC 患者报告的癌症家族史（29.9%比 10.7%，P<0.01）和饮酒（54.5%比 43.2%，P<0.01）比例显著高于对照组。与对照组相比，患者中不规律进食者的比例显著更高（66.7%比 24.4%，P<0.01）。IL-1B+3954CT 或 TT 变异基因型与 GC 风险显著相关[调整后的比值比（OR），2.94；95%置信区间（CI），1.06-8.15]，而 IL-1RN-9876G/A、IL-1RN-9739A/G 和 IL-1RN-9091A/C 的变体则没有相关性（调整后的 OR，1.29，95% CI，0.77-2.16；调整后的 OR，1.25，95% CI，0.75-2.07；调整后的 OR，1.09，95% CI，0.71-1.67）。IL-1RN 三个多态性建立的单倍型与 GC 风险无关。本研究中，IL-1B+3954C/T 多态性与 GC 风险相关。饮酒、饮食不规律和癌症家族史等生活方式和环境因素增加了患病风险。
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