Faculty of Medicine, Institute of Epidemiology, University of Belgrade, Visegradska 26, 11000, Belgrade, Serbia.
Qual Life Res. 2014 Apr;23(3):1027-37. doi: 10.1007/s11136-013-0535-1. Epub 2013 Oct 1.
The aim of this study was to determine the changes in the health-related quality of life (HRQoL) and predictors of change among patients with multiple sclerosis (MS) at 3 and 6 years during the follow-up period.
A group of 109 consecutive MS patients (McDonald's criteria) referred to the Clinic of Neurology, Belgrade, were enrolled in the study. At three time points during the study (baseline, and at 3 and 6 years during the follow-up period), the HRQoL (measured by MSQoL-54), Expanded Disability Status Scale, and Hamilton Rating Scale for Depression and Fatigue Severity Scale were assessed.
During the study period, 93 patients provided both follow-up assessments. Statistically significant deterioration in the HRQoL at each subsequent time point was detected for all scales of the MSQoL-54 except for the pain and change in health scales. A higher level of education was a significant prognostic factor for a better HRQoL on the cognitive function scale throughout the entire period of observation, while marital status (single, including divorced and widowed) and increased age at the onset of MS had significant predictive values of poorer quality-of-life scores on the overall quality-of-life scale at 6-year follow-up. Higher levels of physical disability and depression at baseline were statistically significant prognostic markers for deterioration in HRQoL for the majority of MSQoL-54 scales during the entire follow-up period.
Our study suggests that baseline demographic and clinical characteristics could be applied as prognostic markers of the HRQOL for patients diagnosed with MS.
本研究旨在确定多发性硬化症（MS）患者在随访期间的 3 年和 6 年时健康相关生活质量（HRQoL）的变化及其变化的预测因素。
一组 109 名连续的 MS 患者（符合 McDonald 标准）被招募到贝尔格莱德神经病学诊所进行研究。在研究期间的三个时间点（基线以及随访期间的 3 年和 6 年），评估了 HRQoL（通过 MSQoL-54 测量）、扩展残疾状况量表和汉密尔顿抑郁量表和疲劳严重程度量表。
在研究期间，93 名患者提供了两次随访评估。除了疼痛和健康变化量表外，所有 MSQoL-54 量表在随后的每个时间点都显示出 HRQoL 的统计学显著恶化。较高的教育水平是整个观察期认知功能量表 HRQoL 更好的重要预后因素，而婚姻状况（单身，包括离婚和丧偶）和 MS 发病时年龄的增加是 6 年随访时整体生活质量量表生活质量评分较差的重要预测因素。基线时较高的身体残疾和抑郁水平是 HRQoL 在整个随访期间大多数 MSQoL-54 量表恶化的统计学显著预后标志物。
我们的研究表明，基线人口统计学和临床特征可作为诊断为 MS 的患者 HRQOL 的预后标志物。
