Chao N J, Blume K G
Department of Medicine, Stanford University School of Medicine, CA.
West J Med. 1990 Jan;152(1):46-51.
Autologous bone marrow transplantation provides an effective form of "rescue" following high-dose therapy used for treating certain malignant diseases. The high doses of radiotherapy or chemotherapy, or both, should allow for greater tumor cell kill if dose-response to therapy exists for that tumor. The use of autologous bone marrow obviates the need for an HLA-identical donor, and the need for pretransplant immunosuppression; no graft-versus-host disease would ensue. We review in part II the history and background, methods of obtaining autologous stem cells, and details of the results achievable with this type of therapy. We discuss potential difficulties with autologous transplantation, as well as possible future areas of research.
自体骨髓移植为治疗某些恶性疾病的大剂量疗法提供了一种有效的“挽救”形式。如果肿瘤对治疗存在剂量反应，那么高剂量的放疗或化疗，或两者同时使用，应能更有效地杀死肿瘤细胞。使用自体骨髓消除了对 HLA 配型相同供体的需求，以及移植前免疫抑制的需求；不会发生移植物抗宿主病。在第二部分中，我们回顾了其历史背景、获取自体干细胞的方法以及这种治疗方法可取得的详细结果。我们讨论了自体移植可能存在的困难以及未来可能的研究领域。
