Gratwohl A, Hermans J
Department of Internal Medicine, Kantonsspital, Basel, Switzerland.
Bone Marrow Transplant. 1994 Jan;13(1):5-10.
In the year 1992, 203 teams in 26 countries in Europe performed a total of 6065 bone marrow transplantations (BMT). Transplant source in 2666 cases (44%) was an allogeneic donor, in 2171 cases an HLA-identical sibling donor, in 170 a non-identical family donor, in 29 a twin donor and in 296 cases an unrelated volunteer donor. There were 3399 autologous transplants (56%): 2494 autologous BMT, 644 autologous peripheral blood stem cell transplants and 261 combined autologous BM and peripheral blood stem cell transplants. Indications for transplant were leukemias in 2963 patients (49%; 1987 allogeneic, 976 autologous), lymphoproliferative disorders in 1890 patients (31%; 201 allogeneic, 1689 autologous), solid tumors in 739 patients (12%; 10 allogeneic, 739 autologous), aplastic anemia in 194 patients (3%; 193 allogeneic, 1 autologous), thalassemia in 128 patients (2%; allogeneic), inborn errors in 115 patients (2%; allogeneic) and miscellaneous disorders in 36 patients (32 allogeneic, 4 autologous). Compared with an EBMT survey 2 years ago, there was an increase in the number of participating institutions and in the number of transplants performed from all sources. If the 142 teams reporting in 1990 and 1992 are compared alone, there is an increase in unrelated allogeneic BMT and in autologous BMT. There was an increase in autologous transplants for myeloma and lymphoma. These data confirm a continuing trend to apply BMT as a therapeutic modality.
1992年，欧洲26个国家的203个团队共进行了6065例骨髓移植（BMT）。2666例（44%）的移植来源是同种异体供者，其中2171例是人类白细胞抗原（HLA）相同的同胞供者，170例是HLA不相同的家族供者，29例是双胞胎供者，296例是无关志愿供者。有3399例自体移植（56%）：2494例自体骨髓移植，644例自体外周血干细胞移植，261例自体骨髓与外周血干细胞联合移植。移植适应证为白血病2963例（49%；1987例同种异体移植，976例自体移植），淋巴增殖性疾病1890例（31%；201例同种异体移植，1689例自体移植），实体瘤739例（12%；10例同种异体移植，739例自体移植），再生障碍性贫血194例（3%；193例同种异体移植，1例自体移植），地中海贫血128例（2%；均为同种异体移植），先天性疾病115例（2%；均为同种异体移植），其他疾病36例（32例同种异体移植，4例自体移植）。与两年前欧洲骨髓移植协作组（EBMT）的一项调查相比，参与机构的数量以及所有来源的移植例数均有所增加。若仅比较1990年和1992年报告的142个团队，无关同种异体骨髓移植和自体骨髓移植均有所增加。骨髓瘤和淋巴瘤的自体移植有所增加。这些数据证实了将骨髓移植作为一种治疗方式的持续趋势。
