Knesevich J W, Toro F R, Morris J C, LaBarge E
Psychiatry Res. 1985 Mar;14(3):255-63. doi: 10.1016/0165-1781(85)90020-4.
Aphasia, was present in a majority of subjects in a longitudinal study of 43 subjects with senile dementia of the Alzheimer type. Aphasic subjects had a more rapidly progressive course but a lower prevalence of familial cases than the study group, other study groups, or the nonaphasic subjects. Conversely, the lack of aphasia was associated with a higher prevalence of familial cases and a slower rate of progression. It is concluded that senile dementia of the Alzheimer type is a heterogeneous disorder in which the presence of aphasia early in the course signifies a nonfamilial, rapidly progressive variety of illness.
在一项对43例阿尔茨海默型老年痴呆症患者的纵向研究中，大多数受试者存在失语症。与研究组、其他研究组或无失语症的受试者相比，失语症患者病程进展更快，但家族性病例的患病率更低。相反，无失语症与家族性病例的较高患病率和较慢的进展速度相关。得出的结论是，阿尔茨海默型老年痴呆症是一种异质性疾病，病程早期出现失语症表明是一种非家族性、快速进展的疾病类型。
