Muñoz-Blanco J, Yusta B, Martínez-Luque M, González J M
Rev Esp Fisiol. 1985 Mar;41(1):89-93.
The effect of acute intoxication by lindane on the AChE activity in blood plasma and in crude synaptosomal fractions from six CNS areas of rats has been studied. The effect of sodium pentobarbital on the convulsive syndrome caused by the above organochlorine compound is also presented. The joint administration of sodium pentobarbital together with lindane prevented the convulsive reaction which had been produced by lindane alone. In the animals intoxicated by lindane a general increase in the AChE activity both in plasma and in the CNS areas studied has been observed. The combination of sodium pentobarbital and lindane produced a decrease in the AChE activity in all the studied areas with the single exception of the spinal cord. These results are discussed bearing in mind the possible interaction between the GABAergic and cholinergic neurotransmission systems in the CNS.
研究了林丹急性中毒对大鼠六个中枢神经系统区域血浆和粗制突触体组分中乙酰胆碱酯酶（AChE）活性的影响。还介绍了戊巴比妥钠对上述有机氯化合物引起的惊厥综合征的作用。戊巴比妥钠与林丹联合给药可预防仅由林丹引起的惊厥反应。在林丹中毒的动物中，观察到血浆和所研究的中枢神经系统区域中AChE活性普遍增加。戊巴比妥钠和林丹的组合使所有研究区域的AChE活性降低，但脊髓除外。结合中枢神经系统中γ-氨基丁酸能和胆碱能神经传递系统之间可能的相互作用对这些结果进行了讨论。
