Frendéus Björn
BioInvent International AB; Lund, Sweden.
Oncoimmunology. 2013 Aug 1;2(8):e25047. doi: 10.4161/onci.25047. Epub 2013 May 20.
Therapeutic antibodies may mediate antineoplastic effects by altering the biological functions of their target, by directly stimulating the demise of cancer cells or by activating antibody-dependent immune effector mechanisms. We have recently provided in vivo proof-of-concept for a "function-first" target and drug discovery platform in which antibodies against a multitude of tumor-associated antigens are screened for biological effects in a target-unbiased manner.
治疗性抗体可通过改变其靶标的生物学功能、直接刺激癌细胞死亡或激活抗体依赖性免疫效应机制来介导抗肿瘤作用。我们最近为一个“功能优先”的靶标和药物发现平台提供了体内概念验证，该平台以无偏向性的方式筛选针对多种肿瘤相关抗原的抗体的生物学效应。
