Devaud Christel, John Liza B, Westwood Jennifer A, Darcy Phillip K, Kershaw Michael H
Cancer Immunology Research Program; Sir Peter MacCallum Department of Oncology; University of Melbourne; Parkville, VIC Australia.
Oncoimmunology. 2013 Aug 1;2(8):e25961. doi: 10.4161/onci.25961. Epub 2013 Aug 22.
There is much promise in the use of immunotherapy for the treatment of cancer. Approaches such as those using antibodies or adoptive cell transfer can mediate complete tumor regression in a proportion of patients. However, the tumor microenvironment can inhibit immune responses leading to ineffective or suboptimal responses of tumors to immunotherapy in the majority of cases. As our knowledge of the tumor microenvironment increases, many strategies are emerging for changing the immunosuppressive nature of the tumor toward a microenvironment able to support immunity. These strategies aim to enhance the ability of immunotherapies to initiate effective immune responses able to destroy tumors. In this article, we review approaches that use immunomodulators specifically to modify the tumor microenvironment, and their use in combination with other immune-based strategies for cancer therapy.
免疫疗法用于癌症治疗有很大前景。诸如使用抗体或过继性细胞转移等方法可使一部分患者实现肿瘤完全消退。然而，肿瘤微环境可抑制免疫反应，导致在大多数情况下肿瘤对免疫疗法的反应无效或不理想。随着我们对肿瘤微环境的了解不断增加，许多旨在将肿瘤的免疫抑制特性转变为能够支持免疫的微环境的策略正在涌现。这些策略旨在增强免疫疗法引发有效免疫反应以摧毁肿瘤的能力。在本文中，我们综述了专门使用免疫调节剂来改变肿瘤微环境的方法，以及它们与其他基于免疫的癌症治疗策略联合使用的情况。
