Department of Breast Surgery, The First Affiliated Hospital with Nanjing Medical University, 300 Guangzhou Road, Nanjing 210029, China.
World J Surg Oncol. 2013 Oct 1;11:248. doi: 10.1186/1477-7819-11-248.
The association between family history and risk of triple negative breast cancer and ductal carcinoma in situ (DCIS) has not been well investigated, especially in Asian populations. We investigated the association between family history and risk of DCIS or triple negative breast cancer in a Han Chinese population.
A case-control study, comprising 926 breast cancer patients and 1,187 benign breast disease controls, was conducted in our hospital. Multivariate logistic regression was used to assess the relationships between family history and risk of DCIS or triple negative breast cancer.
Subjects with a family history of breast cancer had higher breast cancer risk than those without a family history (odds ratio (OR) = 2.11, 95% confidence interval (CI) = 1.26 to 3.52). Family history was not significantly associated with an increased risk of DCIS (OR = 1.27, 95% CI = 0.36 to 4.46), while family history was significantly associated with an increased risk of invasive breast cancer (OR = 2.22, 95% CI = 1.32 to 3.75), irrespective of triple negative breast cancer (OR = 3.35, 95% CI = 1.43 to 7.88) or non-triple negative breast cancer (OR = 2.14, 95% CI = 1.21 to 3.80).
Our results indicate that having a family history of breast cancer is associated with an increased risk of triple negative breast cancer with a magnitude of association similar to that for non-triple negative breast cancer. Furthermore, family history is not significantly associated with an increased risk of DCIS. Future cohort studies with larger sample sizes are still needed to explore these relationships.
家族史与三阴性乳腺癌和导管原位癌（DCIS）风险之间的关联尚未得到很好的研究，尤其是在亚洲人群中。我们调查了家族史与汉族人群 DCIS 或三阴性乳腺癌风险之间的关系。
在我院进行了一项病例对照研究，共纳入 926 例乳腺癌患者和 1187 例良性乳腺疾病对照。采用多变量 logistic 回归评估家族史与 DCIS 或三阴性乳腺癌风险之间的关系。
有乳腺癌家族史的受试者患乳腺癌的风险高于无家族史者（比值比（OR）=2.11，95%置信区间（CI）=1.26 至 3.52）。家族史与 DCIS 风险增加无关（OR=1.27，95%CI=0.36 至 4.46），而家族史与浸润性乳腺癌风险增加显著相关（OR=2.22，95%CI=1.32 至 3.75），无论是否为三阴性乳腺癌（OR=3.35，95%CI=1.43 至 7.88）或非三阴性乳腺癌（OR=2.14，95%CI=1.21 至 3.80）。
我们的研究结果表明，有乳腺癌家族史与三阴性乳腺癌风险增加相关，其关联程度与非三阴性乳腺癌相似。此外，家族史与 DCIS 风险增加无关。仍需要更大样本量的队列研究来进一步探讨这些关系。
