SNHG1 长非编码 RNA 可能在结直肠腺癌中上调。
SNHG1 Long Noncoding RNA is Potentially Up-Regulated in Colorectal Adenocarcinoma.
机构信息
Department of Genetics, Faculty of Science, Shahid Chamran University of Ahvaz, Ahvaz, Iran.
Department of Medical Genetics, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
出版信息
Asian Pac J Cancer Prev. 2020 Apr 1;21(4):897-901. doi: 10.31557/APJCP.2020.21.4.897.
Colorectal cancer (CRC) is one of the most common types of cancer worldwide. However, the molecular mechanisms involved in CRC initiation and progression is remained to be unknown. It seems that lncRNAs, as the main and lengthy functional transcripts of the genome, have important roles in different cancers such as CRC. CRC-related lncRNAs are reported to be involved in diverse molecular processes such as metastasis, invasion, cell proliferation, and apoptosis. This study was aimed to analyse the expression level of lncRNA SNHG1 in colorectal adenocarcinoma and normal tissues. We performed an in silico analysis on a large cohort and confirmed the results by experimental analysis of clinical samples through real-time PCR. Our findings demonstrated that that SNHG1 is potentially overexpressed in tumor tissues compared with adjacent normal tissues. The expression level of SNHG1 was shown to be potentially associated with clinicopathological features of tumors. The current study suggests the potential role of SNHG1 in colon cancer progression.
结直肠癌（CRC）是全球最常见的癌症类型之一。然而，CRC 发生和发展的分子机制尚不清楚。长链非编码 RNA（lncRNA）作为基因组的主要和长程功能转录本，似乎在不同的癌症中（如 CRC）发挥着重要作用。CRC 相关的 lncRNA 被报道参与多种分子过程，如转移、侵袭、细胞增殖和凋亡。本研究旨在分析结直肠腺癌和正常组织中 lncRNA SNHG1 的表达水平。我们对一个大型队列进行了计算机分析，并通过实时 PCR 对临床样本进行了实验分析来验证结果。我们的研究结果表明，与相邻正常组织相比，SNHG1 在肿瘤组织中可能过度表达。SNHG1 的表达水平与肿瘤的临床病理特征有关。本研究提示 SNHG1 在结肠癌进展中可能发挥作用。
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