Kudriashov B A, Liapina L A, Zvereva E G
Vopr Med Khim. 1985 Mar-Apr;31(2):79-83.
After a single administration (intramuscular or per os) of a complex dicoumarin-heparin into rats its hypocoagulation effect exceeded both in the rate and duration the effect of an equimolar doses of dicoumarin. After an intramuscular administration into rats the complex exhibited the hypocoagulation effect within 55 hrs, dicoumarin--within 31 hr. The hypocoagulation effect of the heparin-dicoumarin complex was maintained within 36 hrs, and the effect of dicumarol--within 14 hrs after administration per os.
在向大鼠单次（肌肉注射或口服）给予双香豆素 - 肝素复合物后，其抗凝作用在速率和持续时间上均超过等摩尔剂量双香豆素的作用。向大鼠肌肉注射后，该复合物在55小时内呈现抗凝作用，双香豆素则在31小时内呈现该作用。肝素 - 双香豆素复合物的抗凝作用在36小时内维持，而双香豆醇口服给药后的作用在14小时内维持。
