Kudriashov B A, Liapina L A
Farmakol Toksikol. 1977 Sep-Oct;40(5):559-63.
When given per os a complex heparin-urea produces in the organism an intensive anticoagulant and fibrinolytic background which makes itself manifest in 1 hour time and continues to exist for as long as 16 hours after the last (10th) introduction. Upon abolishing the intake of the complex the study figures for the coagulation, anticoagulation and fibrinolytic activity return back to their physiological level. Introduction per os of the complex heparin-urea did not cause any changes in the tissues of the liver, heart, lungs, spleen and kidneys, while administration by the same route of an equivalent amount of urea caused mainly an increased non-fermentative fibrinolysis in the kidneys.
经口给予肝素 - 尿素复合物后,机体中会产生强烈的抗凝和纤溶背景,1小时后显现,并在最后一次(第10次)给药后持续存在长达16小时。停止摄入该复合物后,凝血、抗凝和纤溶活性的研究数据恢复到生理水平。经口给予肝素 - 尿素复合物未引起肝脏、心脏、肺、脾脏和肾脏组织的任何变化,而经相同途径给予等量尿素主要导致肾脏中非发酵性纤溶增加。