母亲孕早期饮酒与妊娠结局的关系。
Association between maternal alcohol consumption in early pregnancy and pregnancy outcomes.
机构信息
Irish Centre for Fetal and Neonatal Translational Research (INFANT), University College Cork, and the National Perinatal Epidemiology Centre, Cork University Maternity Hospital, Wilton, Cork, Ireland; the Department of Maternal and Fetal Medicine and the Division of Women's Health, Women's Health Academic Centre, King's College London and King's Health Partners, London, United Kingdom; the Department of Obstetrics and Gynaecology, Faculty of Medical and Health Sciences, and the National Centre for Growth & Development and Maternal and Fetal Health, Liggins Institute, University of Auckland, Auckland, New Zealand; the Women's and Children's Division, Lyell McEwin Hospital, University of Adelaide, and the School of Paediatrics and Reproductive Health, Robinson Institute, University of Adelaide, Adelaide, South Australia; and the Department of Obstetrics and Gynaecology, St James University Hospital, Leeds, United Kingdom.
出版信息
Obstet Gynecol. 2013 Oct;122(4):830-837. doi: 10.1097/AOG.0b013e3182a6b226.
OBJECTIVE
To investigate the association between alcohol consumption and binge drinking before and during early pregnancy and adverse pregnancy outcomes.
METHODS
We used data from 5,628 nulliparous pregnant participants recruited to the Screening for Pregnancy Endpoints (SCOPE) study, a prospective cohort study. Participants were interviewed at 15 weeks of gestation and information on alcohol intake before pregnancy and until the time of interview was obtained using a standardized questionnaire. Alcohol intake was classified as occasional (1-2 units per week), low (3-7 units per week), moderate (8-14 units per week), and heavy (greater than 14 units per week). Binge alcohol consumption was defined as consumption of 6 or more alcohol units in one session.
RESULTS
Of the 5,628 participants, 1,090 (19%) reported occasional alcohol consumption, 1,383 (25%) low alcohol consumption, 625 (11%) moderate alcohol consumption, and 300 (5%) heavy alcohol consumption. Overall, 1,905 (34%) participants reported binge alcohol consumption in the 3 months before pregnancy, and 1,288 (23%) of these participants reported binge alcohol consumption during the first 15 weeks of pregnancy. Participants who consumed occasional to heavy amounts of alcohol in early pregnancy did not have altered odds of a small-for-gestational-age neonate, reduced birth weight, preeclampsia, or spontaneous preterm birth. Similarly, those who binge drank in early pregnancy did not have altered odds of these adverse pregnancy outcomes.
CONCLUSION
Alcohol consumption in early pregnancy was prevalent in this nulliparous cohort. There was no association between alcohol consumption before 15 weeks of gestation and small for gestational age, reduced birth weight, preeclampsia, or spontaneous preterm birth.
LEVEL OF EVIDENCE
: II.
目的
研究妊娠前和妊娠早期饮酒和 binge 饮酒与不良妊娠结局的关系。
方法
我们使用了来自 5628 名初产妇的 Screening for Pregnancy Endpoints（SCOPE）研究数据，这是一项前瞻性队列研究。参与者在妊娠 15 周时接受了访谈，并使用标准化问卷获得了妊娠前和访谈时的饮酒信息。饮酒摄入量分为偶尔（每周 1-2 单位）、低量（每周 3-7 单位）、中量（每周 8-14 单位）和大量（每周超过 14 单位）。 binge 饮酒定义为一次性饮酒 6 个或更多单位。
结果
在 5628 名参与者中，1090 名（19%）报告偶尔饮酒，1383 名（25%）报告低量饮酒，625 名（11%）报告中量饮酒，300 名（5%）报告大量饮酒。总体而言，1905 名（34%）参与者在妊娠前 3 个月报告 binge 饮酒，其中 1288 名（23%）参与者在妊娠前 15 周报告 binge 饮酒。在妊娠早期饮酒量较大的参与者，其新生儿小于胎龄儿、出生体重降低、子痫前期或自发性早产的几率没有改变。同样，在妊娠早期 binge 饮酒的参与者，其这些不良妊娠结局的几率也没有改变。
结论
在这个初产妇队列中，妊娠早期饮酒很普遍。妊娠 15 周前饮酒与小于胎龄儿、出生体重降低、子痫前期或自发性早产无关。
证据水平
II。
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