牙科恐惧症中基底神经节回路的功能连接改变。
Altered functional connectivity of basal ganglia circuitry in dental phobia.
作者信息
Scharmüller Wilfried, Leutgeb Verena, Schöngaßner Florian, Hermann Andrea, Stark Rudolf, Schienle Anne
机构信息
Department of Clinical Psychology, University of Graz, Universitätsplatz 2/III, A-8010 Graz, Austria and Department of Psychotherapy and Systems Neuroscience, Bender Institute of Neuroimaging, University of Giessen, Otto-Behaghel-Str.10, 35394 Giessen, Germany.
Department of Clinical Psychology, University of Graz, Universitätsplatz 2/III, A-8010 Graz, Austria and Department of Psychotherapy and Systems Neuroscience, Bender Institute of Neuroimaging, University of Giessen, Otto-Behaghel-Str.10, 35394 Giessen, Germany Department of Clinical Psychology, University of Graz, Universitätsplatz 2/III, A-8010 Graz, Austria and Department of Psychotherapy and Systems Neuroscience, Bender Institute of Neuroimaging, University of Giessen, Otto-Behaghel-Str.10, 35394 Giessen, Germany
出版信息
Soc Cogn Affect Neurosci. 2014 Oct;9(10):1584-8. doi: 10.1093/scan/nst150. Epub 2013 Oct 1.
Recent symptom provocation studies that compared patients suffering from dental phobia with healthy controls identified hyperactivation of basal ganglia structures, but none have assessed striatal functional connectivity. We reanalyzed data from a previous functional magnetic resonance imaging study on dental phobia. Patients (20 men, 25 women) and healthy controls (18 men, 23 women) had been exposed to pictures showing dental treatment, and neutral contents. We conducted connectivity analyses via psychophysiological interactions (PPIs). Relative to non-phobic controls, the patients showed decreased connectivity between prefrontal and basal ganglia regions. Moreover, the clinical group was characterized by increased internal basal ganglia connectivity, which was more pronounced in female compared with male patients. This study provides first evidence for an altered information flow within a fronto-striatal network in dentophobic individuals during visual symptom provocation, which can be considered a neuromarker of this disorder.
最近的症状激发研究比较了患有牙科恐惧症的患者和健康对照者，发现基底神经节结构存在过度激活，但均未评估纹状体功能连接性。我们重新分析了之前一项关于牙科恐惧症的功能磁共振成像研究的数据。患者（20名男性，25名女性）和健康对照者（18名男性，23名女性）观看了展示牙科治疗的图片和中性内容的图片。我们通过心理生理交互作用（PPI）进行连接性分析。相对于无恐惧症的对照者，患者的前额叶和基底神经节区域之间的连接性降低。此外，临床组的特征是基底神经节内部连接性增加，女性患者比男性患者更明显。这项研究首次证明了在视觉症状激发期间，牙科恐惧症患者的额纹状体网络内信息流发生改变，这可被视为该疾病的一种神经标志物。
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