人类基因组中具有边界和增强子序列的复合顺式调控元件。
Compound cis-regulatory elements with both boundary and enhancer sequences in the human genome.
机构信息
School of Biology, Georgia Institute of Technology, Atlanta, GA 30332, USA, Buck Institute for Research on Aging, Novato, CA 94945, USA and PanAmerican Bioinformatics Institute, Santa Marta, Magdalena, Colombia.
出版信息
Bioinformatics. 2013 Dec 15;29(24):3109-12. doi: 10.1093/bioinformatics/btt542. Epub 2013 Oct 1.
MOTIVATION
It has been suggested that presumably distinct classes of genomic regulatory elements may actually share common sets of features and mechanisms. However, there has been no genome-wide assessment of the prevalence of this phenomenon.
RESULTS
To evaluate this possibility, we performed a bioinformatic screen for the existence of compound regulatory elements in the human genome. We identified numerous such colocated boundary and enhancer elements from human CD4(+) T cells. We report evidence that such compound regulatory elements possess unique chromatin features and facilitate cell type-specific functions related to inflammation and immune response in CD4(+) T cells.
动机
据推测，不同类别的基因组调控元件可能实际上共享一组共同的特征和机制。然而，尚未对这种现象的普遍性进行全基因组评估。
结果
为了评估这种可能性，我们在人类基因组中进行了生物信息学筛选，以寻找复合调控元件的存在。我们从人类 CD4(+) T 细胞中鉴定出许多这样的同位边界和增强子元件。我们报告了证据表明，这种复合调控元件具有独特的染色质特征，并促进了与 CD4(+) T 细胞中的炎症和免疫反应相关的细胞类型特异性功能。
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