Equipe Communication Intercellulaire et Infections Microbiennes, Centre de Recherche Interdisciplinaire en Biologie (CIRB), Collège de France, Paris, France.
Cold Spring Harb Perspect Med. 2013 Oct 1;3(10):a016717. doi: 10.1101/cshperspect.a016717.
As opposed to other invasive pathogens that reside into host cells in a parasitic mode, Shigella, the causative agent of bacillary dysentery, invades the colonic mucosa but does not penetrate further to survive into deeper tissues. Instead, Shigella invades, replicates, and disseminates within the colonic mucosa. Bacterial invasion and spreading in intestinal epithelium lead to the elicitation of inflammatory responses responsible for the tissue destruction and shedding in the environment for further infection of other hosts. In this article, we highlight specific features of the Shigella arsenal of virulence determinants injected by a type III secretion apparatus (T3SA) that point to the targeting of intestinal epithelial cells as a discrete route of invasion during the initial event of the infectious process.
与其他以寄生方式存在于宿主细胞内的侵袭性病原体不同，志贺氏菌是细菌性痢疾的病原体，它侵袭结肠黏膜，但不会进一步穿透以在更深的组织中存活。相反，志贺氏菌在结肠黏膜内侵袭、复制和传播。细菌入侵和在肠上皮内扩散导致引发炎症反应，导致组织破坏和脱落到环境中，以便进一步感染其他宿主。在本文中，我们强调了志贺氏菌毒力决定簇的特定特征，这些特征由 III 型分泌系统（T3SA）注入，表明在感染过程的初始事件中，针对肠上皮细胞是一种独特的入侵途径。
