Gill Manmeet Kaur, Makkar Manisha, Bains Satinder Pal Singh
Senior Resident, Department of Pathology, SR in UCMS/GTBH , Delhi, India .
J Clin Diagn Res. 2013 Aug;7(8):1702-3. doi: 10.7860/JCDR/2013/5555.3259. Epub 2013 Aug 1.
Solitary Plasmacytoma of the Skull (SPS) is very rare and only 35 cases have been reported in the English literature. It remains controversial whether a solitary plasmacytoma of the skull is essentially identical with a Solitary Plasmacytoma of Bone (SPB) or not. A solitary plasmacytoma of bone, which includes a solitary plasmacytoma of the skull, is characterized by a radiologically solitary bone lesion, neoplastic plasma cells in the biopsy specimen, fewer than 5% plasma cells in bone marrow, less than 2.0 g/dl monoclonal protein in the serum when it is present and a negative urine test for Bence Jones protein (monoclonal light chain). A solitary plasmacytoma of bone tends to disseminate or progress to multiple myeloma, even as long as 7-23 years after its presentation.
颅骨孤立性浆细胞瘤（SPS）非常罕见，英文文献中仅报道过35例。颅骨孤立性浆细胞瘤与骨孤立性浆细胞瘤（SPB）本质上是否完全相同仍存在争议。骨孤立性浆细胞瘤，包括颅骨孤立性浆细胞瘤，其特征为放射学上的孤立性骨病变、活检标本中的肿瘤性浆细胞、骨髓中浆细胞少于5%、血清中存在单克隆蛋白时低于2.0 g/dl以及本-周蛋白（单克隆轻链）尿检阴性。骨孤立性浆细胞瘤易于播散或进展为多发性骨髓瘤，甚至在其出现后长达7至23年。
