Tanaka M, Shibui S, Nomura K, Nakanishi Y
Neurosurgery Division, National Cancer Center Hospital, Tokyo, Japan.
Jpn J Clin Oncol. 1998 Oct;28(10):626-30. doi: 10.1093/jjco/28.10.626.
Solitary plasmacytoma of the skull is very rare and only 35 cases have been reported in the English literature. It remains controversial whether solitary plasmacytoma of the skull is essentially identical with solitary plasmacytoma of bone or not. Solitary plasmacytoma of bone including solitary plasmacytoma of the skull is characterized by a radiologically solitary bone lesion, neoplastic plasma cells in the biopsy specimen, fewer than 5% plasma cells in bone marrow, less than 2.0 g/dl monoclonal protein in the serum when present and negative urine test for Bence Jones protein (monoclonal light chain). Solitary plasmacytoma of bone tends to disseminate or progress to multiple myeloma even as long as 7-23 years after presentation. We report the first case of solitary plasmacytoma of the skull in which both beta2-microglobulin for detection of early renal disturbance and neoplastic plasma cell labeling index for detection of DNA synthesis were examined in order to predict the clinical course of solitary plasmacytoma of the skull.
颅骨孤立性浆细胞瘤非常罕见，英文文献中仅报道过35例。颅骨孤立性浆细胞瘤与骨孤立性浆细胞瘤本质上是否相同仍存在争议。包括颅骨孤立性浆细胞瘤在内的骨孤立性浆细胞瘤的特征为：放射学上表现为孤立性骨病变，活检标本中有肿瘤性浆细胞，骨髓中浆细胞少于5%，血清中单克隆蛋白（若存在）低于2.0 g/dl，尿本-周蛋白（单克隆轻链）检测为阴性。骨孤立性浆细胞瘤即使在出现后长达7至23年也倾向于播散或进展为多发性骨髓瘤。我们报告了首例颅骨孤立性浆细胞瘤病例，为预测颅骨孤立性浆细胞瘤的临床病程，对用于检测早期肾脏损害的β2微球蛋白和用于检测DNA合成的肿瘤性浆细胞标记指数进行了检测。
