Spencer K, Carpenter P
Br Med J (Clin Res Ed). 1985 Jun 29;290(6486):1940-3. doi: 10.1136/bmj.290.6486.1940.
A report was made on the outcome of a four year retrospective study in 27 064 pregnancies, of the clinical efficiency, sensitivity, and specificity of a screening programme for Down's syndrome based on reported strategies related to the measurement of maternal serum alpha fetoprotein. This study identified 27 pregnancies affected by Down's syndrome with a median multiple of the median maternal serum alpha fetoprotein concentration of 0.82. This figure is considerably higher than that obtained from previous reports on this subject. With an age related multiple of the median maternal serum alpha fetoprotein strategy, 30.8% of Down's affected pregnancies were identified as well as 11.6% of unaffected pregnancies. Perhaps a United Kingdom collaborative study should begin to investigate the reasons for such wide population variance in the reports for the median multiple of the median for Down's affected pregnancies. Until such studies are carried out, screening for Down's syndrome based on low maternal serum alpha fetoprotein concentration is premature.
一份关于对27064例妊娠进行的为期四年回顾性研究结果的报告，该研究涉及基于与孕妇血清甲胎蛋白测量相关报告策略的唐氏综合征筛查项目的临床效率、敏感性和特异性。该研究确定了27例受唐氏综合征影响的妊娠，孕妇血清甲胎蛋白浓度中位数的中位数倍数为0.82。这个数字远高于此前关于该主题的报告所得到的数字。采用与年龄相关的孕妇血清甲胎蛋白浓度中位数倍数策略，30.8%受唐氏综合征影响的妊娠被识别出来，同时11.6%未受影响的妊娠也被识别出来。或许英国的一项合作研究应该开始调查唐氏综合征影响妊娠的中位数倍数报告中出现如此大的人群差异的原因。在进行此类研究之前，基于低孕妇血清甲胎蛋白浓度进行唐氏综合征筛查还为时过早。
