Reynolds Timothy M
Clinical Chemistry Department, Queen's Hospital, Burton-on-Trent, Staffordshire, United Kingdom.
Clin Biochem Rev. 2009 Nov;30(4):187-96.
Modern medicine has given us the power to identify many diseases before they occur and apply preventative measures so that morbidity and mortality may be avoided. When these screening measures are offered to someone who is capable of making an informed decision to proceed, they may be uncontroversial but may actually cause more harm than good. In antenatal screening, it is difficult to define who the patient is, because there are several possibilities: the pregnant woman, the foetus, or the family. Consequently, it can be difficult to identify whether the treatment offered is in the best interest of all concerned. Our growing knowledge about the human genome will in future give us more power to be able to identify undesirable traits, but there is no strict definition where the line of acceptability lies. The eugenic excesses of the mid-20(th) century are often cited as a reason why antenatal screening is bad. The story of King Canute informs us that defining a 'line in the sand' cannot prevent the rising tide of medical capability overwhelming any arbitrary level of acceptability. This paper discusses the history of eugenics from Sparta to the modern day and attempts to give some perspective on this crucial policy area. No one paper can provide the answer: it is necessary that society as a whole debates where it wishes to go...
现代医学使我们有能力在许多疾病发生之前就识别它们,并采取预防措施,从而避免发病和死亡。当这些筛查措施提供给有能力做出明智决定继续进行的人时,它们可能没有争议,但实际上可能弊大于利。在产前筛查中,很难界定谁是患者,因为存在几种可能性:孕妇、胎儿或家庭。因此,很难确定所提供的治疗是否符合所有相关方的最大利益。我们对人类基因组不断增长的了解,未来将使我们更有能力识别不良特征,但对于可接受性的界限并没有严格的定义。20世纪中叶优生学的过度行为常被引为产前筛查不好的一个原因。卡努特国王的故事告诉我们,划定一条“底线”并不能阻止医疗能力的浪潮压倒任何任意的可接受水平。本文讨论了从斯巴达至今的优生学历史,并试图对这一关键政策领域提供一些观点。没有一篇论文能给出答案:整个社会有必要就其希望走向何方展开辩论……