Bisby M A, Keen P
Brain Res. 1985 Jun 17;336(2):201-6. doi: 10.1016/0006-8993(85)90646-8.
The regeneration rate of peripheral nerve axons containing substance P-like immunoreactivity (SPLI) was measured in rat sciatic nerve by radioimmunoassay of SPLI in nerve segments 2, 4 and 6 days after a test lesion made by briefly crushing the nerve at the hip. The regeneration rate of the fastest growing sensory axons was also measured in the same nerves using the pinch-reflex procedure. Three groups of animals were compared: group S, which received only the single test lesion, had regeneration rates of 3.57 +/- 0.26 (S.E.) mm/day for SPLI-containing axons and 3.53 +/- 0.14 mm/day for the fastest growing sensory axons. Group A/H, which received a conditioning lesion on the tibial nerve at the ankle 7 days prior to the test lesion at the hip, had a regeneration rate for SPLI-containing axons which was not significantly different from group S, of 3.35 +/- 0.17 mm/day. However, the regeneration rate for the sensory axons was significantly increased to 4.60 +/- 0.23 mm/day. Group H/H, which received both conditioning and test lesions at the hip, once again separated by 7 days, showed a significant increase in regeneration rate of SPLI-containing axons to 5.50 +/- 0.33 mm/day and a further increase over group A/H in the regeneration rate of sensory axons to 6.70 +/- 0.25 mm/day. We conclude that the small-diameter, unmyelinated axons containing SPLI in peripheral nerve normally regenerate at the same rate as the fastest growing sensory axons.(ABSTRACT TRUNCATED AT 250 WORDS)
通过对大鼠坐骨神经中P物质样免疫反应性（SPLI）进行放射免疫测定，来测量在髋部短暂挤压神经造成试验性损伤后2天、4天和6天神经节段中含SPLI的周围神经轴突的再生速率。同时，使用捏反射程序测量同一神经中生长最快的感觉轴突的再生速率。比较了三组动物：仅接受单次试验性损伤的S组，含SPLI轴突的再生速率为3.57±0.26（标准误）毫米/天，生长最快的感觉轴突的再生速率为3.53±0.14毫米/天。A/H组在髋部试验性损伤前7天对踝部的胫神经进行了预处理损伤，其含SPLI轴突的再生速率与S组无显著差异，为3.35±0.17毫米/天。然而，感觉轴突的再生速率显著提高至4.60±0.23毫米/天。H/H组在髋部接受了预处理和试验性损伤，同样间隔7天，结果显示含SPLI轴突的再生速率显著提高至5.50±0.33毫米/天，感觉轴突的再生速率相对于A/H组进一步提高至6.70±0.25毫米/天。我们得出结论，周围神经中含SPLI的小直径无髓鞘轴突通常与生长最快的感觉轴突以相同速率再生。（摘要截短于250字）
