通过注射载有干细胞的纳米颗粒支架在颅骨缺损处形成骨。
Bone formation in calvarial defects by injectable nanoparticular scaffold loaded with stem cells.
机构信息
Islamic Azad University, Department of Biomaterial Engineering , Tonekabon Branch , Iran +98 1924274415 ; +98 192 427 4411 ;
出版信息
Expert Opin Biol Ther. 2013 Dec;13(12):1653-62. doi: 10.1517/14712598.2013.840284. Epub 2013 Oct 3.
OBJECTIVE
Calcium phosphates are one of biomaterials that are used for bone regeneration. In this study, calcium phosphate nanoparticles such as hydroxyapatite (HA)/fluorapatite (FA),with chitosan gel filled with unrestricted somatic stem cells (USSCs) were used for healing calvarial bone in rat model.
METHODS
The healing effects of these injectable scaffolds, with and without stem cells, in bone regeneration were investigated by computed tomography (CT) analysis and pathology assays after 28 days of grafting.
RESULTS
The results of CT analysis showed that bone regeneration on the scaffolds, and the amounts of regenerated new bone for USSC scaffold were significantly greater than the scaffold without cell and untreated controls.
CONCLUSION
Therefore, the combination of scaffold especially with USSC could be considered as a useful method for bone regeneration.
目的
钙磷是一种用于骨再生的生物材料。在这项研究中，使用了包含壳聚糖凝胶和未受限体干细胞（USSC）的羟磷灰石（HA）/氟磷灰石（FA）钙磷纳米颗粒来治疗大鼠模型的颅骨骨缺损。
方法
通过 28 天的移植后计算机断层扫描（CT）分析和病理检测，研究了这些可注射支架（有无干细胞）在骨再生中的愈合效果。
结果
CT 分析结果表明，支架上的骨再生情况，以及 USSC 支架再生新骨的量明显大于无细胞支架和未治疗对照组。
结论
因此，支架尤其是与 USSC 结合可以被认为是一种用于骨再生的有用方法。
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