Rutgers University School of Public Health, Department of Environmental & Occupational Health, Center for Global Public Health, Piscataway, NJ, USA.
Immunotherapy. 2013 Oct;5(10):1117-26. doi: 10.2217/imt.13.111.
TB is an infectious disease that still has an enormous impact on public health worldwide. With the continuous increasing epidemic of multidrug-resistant TB, new drugs and vaccines are urgently needed. In the last decade there has been a broad advance in the knowledge of innate immunity in TB. Together with the growing research regarding immunomodulators, new promising insights have been developed that can contribute in the control of TB. This is the case of antimicrobial peptides, which can be potential therapeutic or adjuvant agents. The current high cost of antimicrobial peptide synthesis may be a current deterrent for treatment; antimicrobial peptide-inducers can be an alternative for low-cost treatment and/or adjuvants.
结核病是一种传染病，仍然对全球公共卫生造成巨大影响。随着耐多药结核病的流行不断增加，急需新的药物和疫苗。在过去十年中，人们对结核病的先天免疫有了广泛的了解。随着对免疫调节剂的研究不断增加，新的有希望的见解已经被开发出来，可以有助于控制结核病。抗菌肽就是这种情况，它可能是一种有前途的治疗或佐剂药物。目前抗菌肽合成成本高可能是治疗的一个障碍；抗菌肽诱导剂可以作为低成本治疗和/或佐剂的替代物。
