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配子-胚胎冷冻保存与肿瘤生育力相关的伦理困境。

Ethical quandaries in gamete-embryo cryopreservation related to oncofertility.

机构信息

Board certified obstetrician gynecologist with fellowship training in pediatric and adolescent gynecology. Specialist in Family Law, certified by the Ohio State Bar and a founding member of the respected American Academy of Assisted Reproduction Technology Attorneys. Division chief for Pediatric & Adolescent Gynecology at Cincinnati Children's. Medical and Scientific Director at the Arizona Reproductive Institute in Tucson, AZ.

出版信息

J Law Med Ethics. 2013 Fall;41(3):711-9. doi: 10.1111/jlme.12081.

DOI:10.1111/jlme.12081
PMID:24088162
Abstract

While cancer rates continue to increase, therapy has dramatically decreased the mortality rates. The increased efficacy of current therapies may unfortunately have profound toxic effects on gamete function in both adolescent and reproductive age groups, with infertility as an expected consequence of cancer therapy. Significant progress in the advancement of fertility preservation therapies provides realistic options for future fertility in cancer survivors. However, a number of challenging issues need to be considered when presenting fertility preservation options. This overview highlights some of these considerations including religious-cultural-ethical values, access to care and cost of services, developmental capacity and consent, and posthumous reproduction.

摘要

尽管癌症发病率持续上升,但治疗方法已显著降低了死亡率。当前疗法的疗效提高,可能会对青少年和生殖年龄组的配子功能产生深远的毒性影响,不孕是癌症治疗的预期后果。生育力保存疗法的显著进步为癌症幸存者的未来生育提供了现实选择。然而,在提供生育力保存选择时,需要考虑一些具有挑战性的问题。本文概述了其中的一些注意事项,包括宗教文化伦理价值观、获得护理和服务的机会和成本、发育能力和同意,以及死后繁殖。

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