Vijay Manneganti, Prasad Rachapudi Badari Narayana, Devi Bethala Lakshmi Anu Prabhavathi
Centre for Lipid Research, Indian Institute of Chemical Technology.
J Oleo Sci. 2013;62(10):849-55. doi: 10.5650/jos.62.849.
A convinent and efficient method was developed for the synthesis of 1,2-azidoalcohols by ring opening of terminal epoxides with sodium azide employing glycerol-based sulphonic acid functionalized carbon as heterogeneous catalyst in aqueous acetonitrile. The reaction is highly regioselective and affords the corresponding products in excellent yields (78-100%) under mild reaction conditions. The catalyst exhibited efficient reusability without loosing its activity even after 5 cycles of azidolysis of methyl 10,11-epoxy undecanoate under optimized conditions within 2 h.
开发了一种简便高效的方法，以甘油基磺酸官能化碳为多相催化剂，在乙腈水溶液中通过叠氮化钠使末端环氧化物开环来合成1,2-叠氮醇。该反应具有高度的区域选择性，在温和的反应条件下能以优异的产率（78-100%）得到相应产物。在优化条件下，即使在2小时内对10,11-环氧十一烷酸甲酯进行5次叠氮解循环后，该催化剂仍表现出高效的可重复使用性且不失活。
